Flash Glucose Monitoring Can Accurately Reflect Postprandial Glucose Changes in Healthy Adults in Nutrition Studies

Objective: This study investigated the accuracy of a flash glucose monitoring system (FGMS) in a postprandial setting. Methods: Ten fasted adults without diabetes wore the FGMS sensors then consumed a standard breakfast. Their glucose levels were subsequently recorded for 2 hours, both by the FGMS and by measuring capillary glucose levels using the glucose oxidase method. The accuracy of the FGMS data was assessed using the accuracy limits stated in ISO 15197:2013. Results: FGMS measurements were mostly lower than glucose oxidase measurements (mean absolute relative difference +/- SD: 25.4 +/- 17.0%, p < 0.001). However, the maximum difference from baseline captured by the two methods was not significantly different (mean +/- SD, glucose oxidase: 58.5 +/- 18.9 mg/dl; FGMS, 54.4 +/- 28.9 mg/dl, p = 0.366). Conclusions: FGMS could track the incremental glycaemic excursions after meals in adults without diabetes, yet further studies with greater sample sizes are needed to confirm this finding.