Nickel-catalyzed regio- and stereoselective hydrophosphinylation of internal ynamides with H-phosphinates

被引：3

作者：

Kinbara, Atsushi ^{[1
]}

Kasai, Haruka ^{[1
]}

Sato, Kaede ^{[1
]}

Watanabe, Yuri ^{[1
]}

Yamagishi, Takehiro ^{[2
]}

机构：

[1] Ohu Univ, Sch Pharm, 31-1 Misumido,Tomita Machi, Koriyama, Fukushima 9638611, Japan

[2] Hokkaido Univ Sci, Dept Med Chem, Teine Ku, 15-4-1 Maeda 7 Jo, Sapporo, Hokkaido 0068585, Japan

来源：

TETRAHEDRON | 2018年 / 74卷 / 49期

关键词：

Hydrophosphinylation; Internal ynamides; Phosphinic acid derivatives; ALKYNYL BROMIDES; 3-COMPONENT UGI; BOND-FORMATION; INHIBITORS; ESTERIFICATION; AMIDATION; EFFICIENT; ANALOGS; ALKENES;

D O I：

10.1016/j.tet.2018.10.042

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the catalytic hydrophosphinylation of internal ynamides with H-phosphinates has been developed for the first time. The protocol employing the catalyst generated from NiBr2 and PPh3 could be applied to several types of ynamides and H-phosphinates, affording (E)-beta-aminovinylphosphinates in a highly regio- and stereoselective manner. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：7068 / 7073

页数：6

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