Improved surgical margin definition by narrow band imaging for resection of oral squamous cell carcinoma: A prospective gene expression profiling study

被引：32

作者：

Farah, Camile S. ^{[1
,2
]}

Dalley, Andrew J. ^{[1
]}

Phan Nguyen ^{[3
]}

Batstone, Martin ^{[1
,4
]}

Kordbacheh, Farzaneh ^{[1
]}

Perry-Keene, Joanna ^{[5
]}

Fielding, David ^{[6
]}

机构：

[1] Univ Queensland, Clin Res Ctr, Brisbane, Qld, Australia

[2] Australian Ctr Oral Oncol Res & Educ, Brisbane, Qld, Australia

[3] Royal Adelaide Hosp, Dept Thorac Med, Adelaide, SA, Australia

[4] Royal Brisbane & Womens Hosp, Maxillofacial Unit, Brisbane, Qld, Australia

[5] Royal Brisbane & Womens Hosp, Dept Pathol, Brisbane, Qld, Australia

[6] Royal Brisbane & Womens Hosp, Dept Thorac Med, Brisbane, Qld, Australia

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷 / 06期

关键词：

surgical margins; oral squamous cell carcinoma; narrow band imaging; prevention of second cancers; microarray analysis; EPITHELIAL DYSPLASIA; LOCAL RECURRENCE; QUALITY-CONTROL; LESIONS; HEAD; PACKAGE; CAVITY;

D O I：

10.1002/hed.23989

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Incomplete primary tumor excision contributes to localized postsurgical recurrence of oral squamous cell carcinoma (OSCC). The purpose of this study was to provide molecular evidence that surgical margin definition using narrow band imaging (NBI) resulted in more complete OSCC excision than conventional white light (WL) panendoscopy. Methods. Molecular divergence among tumor, WL, and NBI-defined surgical margins was compared in 18 patients through microarray analysis (GeneChip U133-plus-2.0). Results. The numbers of differentially expressed genes (NBI54387; WL53266; vs tumor) signified that NBI placed margins into less involved tissue than WL examination. Principal component analysis segregated tumor, WL, and NBI tissues appropriately based solely on mRNA profiles, and unsupervised hierarchical clustering identified 4 patients (22%) who benefited directly from NBI surgical margin definition. Gene ontology enrichment indicated increasing cell phenotypic diversity: tumor <WL<NBI. Conclusion. Resection to NBI-defined margins will leave less dysplastic and malignant residual tissue and thereby increase ablative surgery success rates. (C) 2015 Wiley Periodicals, Inc.

引用

页码：832 / 839

页数：8

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