Association of genetic variants in the 3'UTR of HLA-G with Recurrent Pregnancy Loss

被引:30
作者
Amodio, Giada [1 ]
Canti, Valentina [2 ]
Maggio, Luana [3 ]
Rosa, Susanna [3 ]
Castiglioni, Maria Teresa [3 ]
Rovere-Querini, Patrizia [2 ,4 ]
Gregori, Silvia [1 ]
机构
[1] IRCCS San Raffaele Sci Inst, Div Regenerat Med Stem Cells & Gene Therapy, San Raffaele Telethon Inst Gene Therapy SR Tiget, Via Olgettina 60, I-20132 Milan, Italy
[2] IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Via Olgettina 58, I-20132 Milan, Italy
[3] IRCCS San Raffaele Sci Inst, Obstetr & Gynecol Unit, Milan, Italy
[4] Univ Vita Salute San Raffaele, Via Olgettina 60, I-20132 Milan, Italy
关键词
Unexplained Recurrent Pregnancy Loss; (RPL); HLA-G; 3'UTR polymorphisms of HLA-G; G MESSENGER-RNA; 3' UNTRANSLATED REGION; EXTRAVILLOUS TROPHOBLASTS; INSERTION POLYMORPHISM; G EXPRESSION; G GENOTYPE; ANTIGEN; SUSCEPTIBILITY; MISCARRIAGE; INSIGHTS;
D O I
10.1016/j.humimm.2016.06.020
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human Leukocyte Antigen (HLA)-G is involved in reprogramming immune responses at fetal-maternal interface during pregnancy. We evaluated the genetic diversity of the 3' Un-Translated Region (UTR) of HLA-G, previously associated with HLA-G mRNA post-transcriptional regulation, in women with unexplained Recurrent Pregnancy Loss (RPL), with 2 pregnancy losses (RPL-2, n = 28), or 3 or more pregnancy losses (RPL-3, n = 24), and in 30 women with a history of successful pregnancy. Results showed in RPL-2, but not in RPL-3, women compared to controls: i) higher frequency of the 14 bp Ins allele, in single and in double copy; ii) significantly lower frequency of DelG/X genotype, iii) reduced frequency of the UTR-2, and UTR-3 haplotypes; iv) higher frequencies of the UTR-5, UTR-7, and UTR-8 haplotypes. This pilot study supports the relevance of performing 3'UTR HLA-G genetic screening, not limited to a specific polymorphism, but considering the extended haplotypes, as a possible predictor of pregnancy outcome. (C) 2016 The Authors. Published by Elsevier Inc.
引用
收藏
页码:886 / 891
页数:6
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