Chimeric SHIV that causes CD4+ T cell loss and AIDS in rhesus macaques

被引：39

作者：

Joag, SV

Li, Z

Wang, CY

Jia, FL

Foresman, L

Adany, I

Pinson, DM

Stephens, EB

Narayan, O

机构：

[1] Univ Kansas, Med Ctr, Marion Merrell Dow Lab Viral Pathogenesis, Kansas City, KS 66160 USA

[2] Univ Kansas, Med Ctr, Dept Microbiol, Kansas City, KS 66160 USA

[3] Univ Kansas, Med Ctr, Lab Anim Resources, Kansas City, KS 66160 USA

[4] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66160 USA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1998年 / 27卷 / 2-3期

关键词：

HIV; SIV; primate model; Macaca mulatta; bonnet; Macaca radiata; pig-tailed; Macaca nemestrina; encephalitis; lentivirus;

D O I：

10.1111/j.1600-0684.1998.tb00227.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

By animal to animal passage in rhesus and pig-tailed macaques, we developed a rhesus model of HIV-1 disease in humans. Rhesus macaques infected with a cell-free stock of SHIVKU-2 developed CD4(+) T cell loss, primary lentiviral encephalitis and pneumonia, and AIDS. Six of nine rhesus macaques died within eight months post-inoculation, while the remaining three are at five, five, and eight months post-inoculation, respectively. Animals infected by either mucosal or parenteral routes of infection had a similar course of infection.

引用

页码：59 / 64

页数：6

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