Effect of 30 Hz theta burst transcranial magnetic stimulation on the primary motor cortex in children and adolescents

被引:15
作者
Pedapati, Ernest V. [1 ,2 ]
Gilbert, Donald L. [1 ]
Horn, Paul S. [1 ,3 ]
Huddleston, David A. [1 ]
Laue, Cameron S. [2 ]
Shahana, Nasrin [1 ]
Wu, Steve W. [1 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Neurol, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Child & Adolescent Psychiat, Cincinnati, OH 45229 USA
[3] Cincinnati Childrens Hosp Med Ctr, Div Biostat & Epidemiol, Cincinnati, OH 45229 USA
关键词
repetitive transcranial magnetic stimulation; theta burst stimulation; long-term potentiation; pediatric; neuroplasticity; LONG-TERM POTENTIATION; NONINVASIVE BRAIN-STIMULATION; SYNAPTIC PLASTICITY; CORTICAL PLASTICITY; MOUSE MODEL; EXCITABILITY; FREQUENCY; HIPPOCAMPUS; DISORDERS; INDUCTION;
D O I
10.3389/fnhum.2015.00091
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Fourteen healthy children (13.8 +/- 2.2 years, range 10-16; M:F = 5:9) received 30 Hz intermittent theta burst transcranial magnetic stimulation (iTBS) with a stimulation intensity of 70% of resting motor threshold (RMT) with a total of 300 (iTBS300) pulses. All volunteers were free of neurologic, psychiatric and serious medical illnesses, not taking any neuropsychiatric medications, and did not have any contraindications to transcranial magnetic stimulation. Changes in the mean amplitudes of motor-evoked potentials from baseline following iTBS were expressed as a ratio and assessed from 1 to 10 min (BLOCK1) and 1-30 min (BLOCK2) using repeated-measures analysis of variance. All 14 subjects completed iTBS300 over the dominant primary motor cortex (M1) without any clinically reported adverse events. ITBS300 produced significant M1 facilitation [F-(5,F- 65) = 3.165, p = 0.01] at BLOCK1 and trend level M1 facilitation at BLOCK2 [F-(10,F- 129) = 1.69, p = 0.089]. Although iTBS300 (stimulation duration of 92 s at 70% RMT) delivered over M1 in typically developed children was well-tolerated and produced on average significant facilitatory changes in cortical excitability, the post-iTBS300 neurophysiologic response was variable in our small sample. ITBS300-induced changes may represent a potential neuroplastic biomarker in healthy children and those with neuro-genetic or neuro-psychiatric disorders. However, a larger sample size is needed to address safety and concerns of response variability.
引用
收藏
页数:8
相关论文
共 71 条
[1]  
[Anonymous], 2006, LINEAR MIXED MODELS
[2]   Synaptic plasticity in the human dentate gyrus [J].
Beck, H ;
Goussakov, IV ;
Lie, AL ;
Helmstaedter, C ;
Elger, CE .
JOURNAL OF NEUROSCIENCE, 2000, 20 (18) :7080-7086
[3]   CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].
BENJAMINI, Y ;
HOCHBERG, Y .
JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300
[4]   LONG-TERM SYNAPTIC POTENTIATION [J].
BROWN, TH ;
CHAPMAN, PF ;
KAIRISS, EW ;
KEENAN, CL .
SCIENCE, 1988, 242 (4879) :724-728
[5]   Developmental regulation of the late phase of long-term potentiation (L-LTP) and metaplasticity in hippocampal area CA1 of the rat [J].
Cao, Guan ;
Harris, Kristen M. .
JOURNAL OF NEUROPHYSIOLOGY, 2012, 107 (03) :902-912
[6]   Network Connectivity and Individual Responses to Brain Stimulation in the Human Motor System [J].
Cardenas-Morales, Lizbeth ;
Volz, Lukas J. ;
Michely, Jochen ;
Rehme, Anne K. ;
Pool, Eva-Maria ;
Nettekoven, Charlotte ;
Eickhoff, Simon B. ;
Fink, Gereon R. ;
Grefkes, Christian .
CEREBRAL CORTEX, 2014, 24 (07) :1697-1707
[7]   Mechanisms and Applications of Theta-burst rTMS on the Human Motor Cortex [J].
Cardenas-Morales, Lizbeth ;
Nowak, Dennis A. ;
Kammer, Thomas ;
Wolf, Robert C. ;
Schoenfeldt-Lecuona, Carlos .
BRAIN TOPOGRAPHY, 2010, 22 (04) :294-306
[8]   Treatment of Neurodevelopmental Disorders in Adulthood [J].
Castren, Eero ;
Elgersma, Ype ;
Maffei, Lamberto ;
Hagerman, Randi .
JOURNAL OF NEUROSCIENCE, 2012, 32 (41) :14074-14079
[9]   Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].
Chen, R ;
Classen, J ;
Gerloff, C ;
Celnik, P ;
Wassermann, EM ;
Hallett, M ;
Cohen, LG .
NEUROLOGY, 1997, 48 (05) :1398-1403
[10]   Impact of coil position and electrophysiological monitoring on determination of motor thresholds to transcranial magnetic stimulation [J].
Conforto, AB ;
Z'Graggen, WJ ;
Kohl, AS ;
Rösler, KM ;
Kaelin-Lang, A .
CLINICAL NEUROPHYSIOLOGY, 2004, 115 (04) :812-819