Radiochemical purification of no-carrier-added scandium-47 for radioimmunotherapy

被引：84

作者：

Kolsky, KL ^{[1
]}

Joshi, V ^{[1
]}

Mausner, LF ^{[1
]}

Srivastava, SC ^{[1
]}

机构：

[1] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

来源：

APPLIED RADIATION AND ISOTOPES | 1998年 / 49卷 / 12期

关键词：

D O I：

10.1016/S0969-8043(98)00016-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A procedure, adaptable to large-scale remote operation, was developed to purify no-carrier-added (NCA) (SC)-S-47 from irradiated Ti targets. Methods based on extraction chromatography and cation-exchange chromatography were compared. Results of this comparison led to the development of an optimized procedure based on cation-exchange with Dowex AG 50W-X4 and Sc-47 elution with HCl/HF. This method gave 90-97% overall Sc-47 recovery, with a Ti separation factor greater than 2.4 x 10(-5), and specific activities greater than or equal to 0.9 GBq mu g(-1). Use of the Sc-47 product, for labeling monoclonal antibodies, resulted in consistent labeling yields of greater than or equal to 90%. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1541 / 1549

页数：9

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