Sirtuins and β-cell function

被引：15

作者：

Bordone, L.

Guarente, L.

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Novartis Inst BioMed Res, Dept Diabet & Metab, Cambridge, MA USA

来源：

DIABETES OBESITY & METABOLISM | 2007年 / 9卷

关键词：

beta-cells; calorie restriction; insulin secretion; SIRT1; SIRT4;

D O I：

10.1111/j.1463-1326.2007.00769.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the past century, there have been major advances in medicine, diet and living conditions that have substantially extended the health span of people in the developed world. Over the past decade or so, the science of ageing has made great strides in providing an understanding of the underlying causes of ageing and how diet and genes play into the ageing process. In this essay, we will review some of the recent advances made in the science of sirtuins and beta-cell biology, and discuss how we will apply this knowledge to further the progress of humankind in healthy ageing.

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收藏

页码：23 / 27

页数：5

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