Risk factors and biomarkers of age-related macular degeneration

被引：261

作者：

Lambert, Nathan G. ^{[1
,2
]}

ElShelmani, Hanan ^{[3
]}

Singh, Malkit K. ^{[1
,2
]}

Mansergh, Fiona C. ^{[4
]}

Wride, Michael A. ^{[3
]}

Padilla, Maximilian ^{[1
,2
]}

Keegan, David ^{[5
]}

Hogg, Ruth E. ^{[6
]}

Ambati, Balamurali K. ^{[1
,2
]}

机构：

[1] John A Moran Eye Ctr, Ambati Lab, 65 Mario Capecchi Dr, Salt Lake City, UT USA

[2] Univ Utah, Dept Ophthalmol & Visual Sci, 65 Mario Capecchi Dr, Salt Lake City, UT USA

[3] Univ Dublin, Trinity Coll, Sch Nat Sci, Ocular Dev & Neurobiol Res Grp,Zool Dept, Dublin 2, Ireland

[4] Trinity Coll Dublin, Smurfit Inst Genet, Dublin 2, Ireland

[5] Mater Misericordia Hosp, Eccles St, Dublin 7, Ireland

[6] Inst Clin Sci, Ctr Med Expt, Block A,Grosvenor Rd, Belfast, Antrim, North Ireland

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2016年 / 54卷

基金：

美国国家卫生研究院; 爱尔兰科学基金会;

关键词：

Age-related macular degeneration; Biomarkers; Proteomics; microRNA; sFlt; COMPLEMENT FACTOR-H; ENDOTHELIAL GROWTH-FACTOR; C-REACTIVE PROTEIN; GENOME-WIDE ASSOCIATION; POLYPOIDAL CHOROIDAL VASCULOPATHY; STARGARDT-DISEASE GENE; BODY-MASS INDEX; MICRORNA EXPRESSION PROFILES; PLASMA HOMOCYSTEINE LEVEL; MESSENGER-RNA EXPRESSION;

D O I：

10.1016/j.preteyeres.2016.04.003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A biomarker can be a substance or structure measured in body parts, fluids or products that can affect or predict disease incidence. As age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, much research and effort has been invested in the identification of different biomarkers to predict disease incidence, identify at risk individuals, elucidate causative pathophysiological etiologies, guide screening, monitoring and treatment parameters, and predict disease outcomes. To date, a host of genetic, environmental, proteomic, and cellular targets have been identified as both risk factors and potential biomarkers for AMD. Despite this, their use has been confined to research settings and has not yet crossed into the clinical arena. A greater understanding of these factors and their use as potential biomarkers for AMD can guide future research and clinical practice. This article will discuss known risk factors and novel, potential biomarkers of AMD in addition to their application in both academic and clinical settings. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：64 / 102

页数：39

共 426 条

[61] Association between Variant Y402H in Age-Related Macular Degeneration (AMD) Susceptibility Gene CFH and Treatment Response of AMD: A Meta-Analysis [J].

Chen, Han ;

Yu, Ke-Da ;

Xu, Ge-Zhi .

PLOS ONE, 2012, 7 (08)

[62] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration [J].

Chen, Wei ;

Stambolian, Dwight ;

Edwards, Albert O. ;

Branham, Kari E. ;

Othman, Mohammad ;

Jakobsdottir, Johanna ;

Tosakulwong, Nirubol ;

Pericak-Vance, Margaret A. ;

Campochiaro, Peter A. ;

Klein, Michael L. ;

Tan, Perciliz L. ;

Conley, Yvette P. ;

Kanda, Atsuhiro ;

Kopplin, Laura ;

Li, Yanming ;

Augustaitis, Katherine J. ;

Karoukis, Athanasios J. ;

Scott, William K. ;

Agarwal, Anita ;

Kovach, Jaclyn L. ;

Schwartz, Stephen G. ;

Postel, Eric A. ;

Brooks, Matthew ;

Baratz, Keith H. ;

Brown, William L. ;

Brucker, Alexander J. ;

Orlin, Anton ;

Brown, Gary ;

Ho, Allen ;

Regillo, Carl ;

Donoso, Larry ;

Tian, Lifeng ;

Kaderli, Brian ;

Hadley, Dexter ;

Hagstrom, Stephanie A. ;

Peachey, Neal S. ;

Klein, Ronald ;

Klein, Barbara E. K. ;

Gotoh, Norimoto ;

Yamashiro, Kenji ;

Ferris, Frederick, III ;

Fagerness, Jesen A. ;

Reynolds, Robyn ;

Farrer, Lindsay A. ;

Kim, Ivana K. ;

Miller, Joan W. ;

Corton, Marta ;

Carracedo, Angel ;

Sanchez-Salorio, Manuel ;

Pugh, Elizabeth W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (16) :7401-7406

[63] Assessing Susceptibility to Age-Related Macular Degeneration With Genetic Markers and Environmental Factors [J].

Chen, Yuhong ;

Zeng, Jiexi ;

Zhao, Chao ;

Wang, Kevin ;

Trood, Elizabeth ;

Buehler, Jeanette ;

Weed, Matthew ;

Kasuga, Daniel ;

Bernstein, Paul S. ;

Hughes, Guy ;

Fu, Victoria ;

Chin, Jessica ;

Lee, Clara ;

Crocker, Maureen ;

Bedell, Matthew ;

Salasar, Francesca ;

Yang, Zhenglin ;

Goldbaum, Michael ;

Ferreyra, Henry ;

Freeman, William R. ;

Kozak, Igor ;

Zhang, Kang .

ARCHIVES OF OPHTHALMOLOGY, 2011, 129 (03) :344-351

[64] Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis [J].

Cheng, AM ;

Byrom, MW ;

Shelton, J ;

Ford, LP .

NUCLEIC ACIDS RESEARCH, 2005, 33 (04) :1290-1297

[65] Genetic Testing in Persons with Age-Related Macular Degeneration and the Use of the AREDS Supplements: To Test or Not to Test? [J].

Chew, Emily Y. ;

Klein, Michael L. ;

Clemons, Traci E. ;

Agron, Elvira ;

Abecasis, Goncalo R. .

OPHTHALMOLOGY, 2015, 122 (01) :212-215

[66] Lutein/Zeaxanthin for the Treatment of Age-Related Cataract AREDS2 Randomized Trial Report No. 4 [J].

Chew, Emily Y. ;

SanGiovanni, John Paul ;

Ferris, Frederick L. ;

Wong, Wai T. ;

Agron, Elvira ;

Clemons, Traci E. ;

Sperduto, Robert ;

Danis, Ronald ;

Chandra, Suresh R. ;

Blodi, Barbara A. ;

Domalpally, Amitha ;

Elman, Michael J. ;

Antoszyk, Andrew N. ;

Ruby, Alan J. ;

Orth, David ;

Bressler, Susan B. ;

Fish, Gary E. ;

Hubbard, George B. ;

Klein, Michael L. ;

Friberg, Thomas R. ;

Rosenfeld, Philip J. ;

Toth, Cynthia A. ;

Bernstein, Paul .

JAMA OPHTHALMOLOGY, 2013, 131 (07) :843-850

[67] Associations between Genetic Polymorphisms of Insulin-like Growth Factor Axis Genes and Risk for Age-Related Macular Degeneration [J].

Chiu, Chung-Jung ;

Conley, Yvette P. ;

Gorin, Michael B. ;

Gensler, Gary ;

Lai, Chao-Qiang ;

Shang, Fu ;

Taylor, Allen .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (12) :9099-9107

[68] Risk Factors for Four-Year Incidence and Progression of Age-Related Macular Degeneration: The Los Angeles Latino Eye Study [J].

Choudhury, Farzana ;

Varma, Rohit ;

McKean-Cowdin, Roberta ;

Klein, Ronald ;

Azen, Stanley P. .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2011, 152 (03) :385-395

[69] Prospective Study of Plasma Homocysteine Level and Risk of Age-related Macular Degeneration in Women [J].

Christen, William G. ;

Cook, Nancy R. ;

Ridker, Paul M. ;

Buring, Julie E. .

OPHTHALMIC EPIDEMIOLOGY, 2015, 22 (02) :85-93

[70] VEGF polymorphisms are associated with neovascular age-related macular degeneration [J].

Churchill, Amanda J. ;

Carter, James G. ;

Lovell, Helen C. ;

Ramsden, Conor ;

Turner, Steven J. ;

Yeung, Anna ;

Escardo, Julia ;

Atan, Denize .

HUMAN MOLECULAR GENETICS, 2006, 15 (19) :2955-2961

← 2 3 4 5 6 7 8 9 10 11 →