Risk factors and biomarkers of age-related macular degeneration

被引：261

作者：

Lambert, Nathan G. ^{[1
,2
]}

ElShelmani, Hanan ^{[3
]}

Singh, Malkit K. ^{[1
,2
]}

Mansergh, Fiona C. ^{[4
]}

Wride, Michael A. ^{[3
]}

Padilla, Maximilian ^{[1
,2
]}

Keegan, David ^{[5
]}

Hogg, Ruth E. ^{[6
]}

Ambati, Balamurali K. ^{[1
,2
]}

机构：

[1] John A Moran Eye Ctr, Ambati Lab, 65 Mario Capecchi Dr, Salt Lake City, UT USA

[2] Univ Utah, Dept Ophthalmol & Visual Sci, 65 Mario Capecchi Dr, Salt Lake City, UT USA

[3] Univ Dublin, Trinity Coll, Sch Nat Sci, Ocular Dev & Neurobiol Res Grp,Zool Dept, Dublin 2, Ireland

[4] Trinity Coll Dublin, Smurfit Inst Genet, Dublin 2, Ireland

[5] Mater Misericordia Hosp, Eccles St, Dublin 7, Ireland

[6] Inst Clin Sci, Ctr Med Expt, Block A,Grosvenor Rd, Belfast, Antrim, North Ireland

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2016年 / 54卷

基金：

美国国家卫生研究院; 爱尔兰科学基金会;

关键词：

Age-related macular degeneration; Biomarkers; Proteomics; microRNA; sFlt; COMPLEMENT FACTOR-H; ENDOTHELIAL GROWTH-FACTOR; C-REACTIVE PROTEIN; GENOME-WIDE ASSOCIATION; POLYPOIDAL CHOROIDAL VASCULOPATHY; STARGARDT-DISEASE GENE; BODY-MASS INDEX; MICRORNA EXPRESSION PROFILES; PLASMA HOMOCYSTEINE LEVEL; MESSENGER-RNA EXPRESSION;

D O I：

10.1016/j.preteyeres.2016.04.003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A biomarker can be a substance or structure measured in body parts, fluids or products that can affect or predict disease incidence. As age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, much research and effort has been invested in the identification of different biomarkers to predict disease incidence, identify at risk individuals, elucidate causative pathophysiological etiologies, guide screening, monitoring and treatment parameters, and predict disease outcomes. To date, a host of genetic, environmental, proteomic, and cellular targets have been identified as both risk factors and potential biomarkers for AMD. Despite this, their use has been confined to research settings and has not yet crossed into the clinical arena. A greater understanding of these factors and their use as potential biomarkers for AMD can guide future research and clinical practice. This article will discuss known risk factors and novel, potential biomarkers of AMD in addition to their application in both academic and clinical settings. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：64 / 102

页数：39

共 426 条

[1] Factor D Inhibitors for the Treatment of AMD Patent Highlight [J].

Abdel-Magid, Ahmed F. .

ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (10) :781-782

[2] Variants in the VEGFA Gene and Treatment Outcome after Anti-VEGF Treatment for Neovascular Age-related Macular Degeneration [J].

Abedi, Farshad ;

Wickremasinghe, Sanjeewa ;

Richardson, Andrea J. ;

Makalic, Enes ;

Schmidt, Daniel F. ;

Sandhu, Sukhpal S. ;

Baird, Paul N. ;

Guymer, Robyn H. .

OPHTHALMOLOGY, 2013, 120 (01) :115-121

[3] Mutation of IGFBP7 Causes Upregulation of BRAF/MEK/ERK Pathway and Familial Retinal Arterial Macroaneurysms [J].

Abu-Safieh, Leen ;

Abboud, Emad B. ;

Alkuraya, Hisham ;

Shamseldin, Hanan ;

Al-Enzi, Shamsa ;

Al-Abdi, Lama ;

Hashem, Mais ;

Colak, Dilek ;

Jarallah, Abdullah ;

Ahmad, Hala ;

Bobis, Steve ;

Nemer, Georges ;

Bitar, Fadi ;

Alkuraya, Fowzan S. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2011, 89 (02) :313-319

[4] Apolipoprotein E Gene Associations in Age-related Macular Degeneration [J].

Adams, Madeleine K. M. ;

Simpson, Julie A. ;

Richardson, Andrea J. ;

English, Dallas R. ;

Aung, Khin Zaw ;

Makeyeva, Galina A. ;

Guymer, Robyn H. ;

Giles, Graham G. ;

Hopper, John ;

Robman, Liubov D. ;

Baird, Paul N. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2012, 175 (06) :511-518

[5] Abdominal Obesity and Age-related Macular Degeneration [J].

Adams, Madeleine K. M. ;

Simpson, Julie A. ;

Aung, Khin Zaw ;

Makeyeva, Galina A. ;

Giles, Graham G. ;

English, Dallas R. ;

Hopper, John ;

Guymer, Robyn H. ;

Baird, Paul N. ;

Robman, Liubov D. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2011, 173 (11) :1246-1255

[6] Prevalence of anti-retinal autoantibodies in different stages of Age-related macular degeneration [J].

Adamus, Grazyna ;

Chew, Emily Y. ;

Ferris, Frederick L. ;

Klein, Michael L. .

BMC OPHTHALMOLOGY, 2014, 14

[7]

Agosta E, 2012, PHARMACOGENOMICS, V13, P1037, DOI [10.2217/pgs.12.77, 10.2217/PGS.12.77]

[8] MMP20 and ARMS2/HTRA1 Are Associated with Neovascular Lesion Size in Age-Related Macular Degeneration [J].

Akagi-Kurashige, Yumiko ;

Yamashiro, Kenji ;

Gotoh, Norimoto ;

Miyake, Masahiro ;

Morooka, Satoshi ;

Yoshikawa, Munemitsu ;

Nakata, Isao ;

Kumagai, Kyoko ;

Tsujikawa, Akitaka ;

Yamada, Ryo ;

Matsuda, Fumihiko ;

Saito, Masaaki ;

Iida, Tomohiro ;

Sugahara, Masako ;

Kurimoto, Yasuo ;

Cheng, Ching-Yu ;

Khor, Chiea-Chuen ;

Wong, Tien-Yin ;

Yoshimura, Nagahisa .

OPHTHALMOLOGY, 2015, 122 (11) :2295-+

[9] Enhanced Susceptibility to Leishmania Infection in Resistant Mice in the Absence of Immediate Early Response Gene X-1 [J].

Akilov, Oleg E. ;

Ustyugova, Irina V. ;

Zhi, Liang ;

Hasan, Tayyaba ;

Wu, Mei X. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (12) :7994-8003

[10] A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy [J].

Allikmets, R ;

Singh, N ;

Sun, H ;

Shroyer, NE ;

Hutchinson, A ;

Chidambaram, A ;

Gerrard, B ;

Baird, L ;

Stauffer, D ;

Peiffer, A ;

Rattner, A ;

Smallwood, P ;

Li, YX ;

Anderson, KL ;

Lewis, RA ;

Nathans, J ;

Leppert, M ;

Dean, M ;

Lupski, JR .

NATURE GENETICS, 1997, 15 (03) :236-246

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