Cutaneous Myelofibrosis With JAK2 V617F Mutation: Metastasis, Not Merely Extramedullary Hematopoiesis!

被引：11

作者：

Fraga, Garth R. ^{[1
]}

Caughron, Samuel K. ^{[2
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA

[2] MAWD Pathol Grp, Kansas City, MO USA

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2010年 / 32卷 / 07期

关键词：

myelofibrosis; extramedullary hematopoiesis; metastasis; JAK2; leukemia; MYELOID METAPLASIA; IDIOPATHIC MYELOFIBROSIS; SKIN; MANIFESTATION; PATHOGENESIS;

D O I：

10.1097/DAD.0b013e3181d3ca2f

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm. There are 31 reported cases of cutaneous involvement by PMF, most of which have been described as "extramedullary hematopoiesis.'' We report a new case of cutaneous involvement by PMF and demonstrate mutation of the Janus kinase 2 gene in the cutaneous lesions. Extramedullary myelofibrosis is best considered a metastatic phenomenon. Reporting such cases as extramedullary hematopoiesis may cause confusion with reactive forms of extramedullary hematopoiesis.

引用

页码：727 / 730

页数：4

共 50 条

[11] The JAK2 V617F somatic mutation, mortality and cancer risk in the general population
Nielsen, Camilla
Birgens, Henrik S.
Nordestgaard, Borge G.
Kjaer, Lasse
Bojesen, Stig E.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (03): : 450 - 453
[12] Prevalence of JAK2 V617F mutation in Indian patients with chronic myeloproliferative disorders
Sazawal, Sudha
Bajaj, Jyoti
Chikkara, Sunita
Jain, Sonal
Bhargava, Rahul
Mahapatra, Manoranjan
Saxena, Renu
INDIAN JOURNAL OF MEDICAL RESEARCH, 2010, 132 (04) : 423 - 427
[13] Morphologic and Molecular Characteristics of De Novo AML With JAK2 V617F Mutation
Hidalgo-Lopez, Juliana E.
Kanagal-Shamanna, Rashmi
Medeiros, L. Jeffrey
Estrov, Zeev
Yin, C. Cameron
Verstovsek, Srdan
Konoplev, Sergej
Jorgensen, Jeffrey L.
Mohammad, M. Mohammad
Miranda, Roberto N.
Zhao, Chong
Lee, John
Zuo, Zhuang
Bueso-Ramos, Carlos E.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2017, 15 (06): : 790 - 796
[14] JAK2 V617F mutation is associated with 5q-syndrome in Chinese
Wong, K. F.
Wong, W. S.
Siu, Lisa L. P.
Lau, T. C.
Chan, N. P.
LEUKEMIA & LYMPHOMA, 2009, 50 (08) : 1333 - 1335
[15] JAK2 V617F Mutation Detection: Laboratory Comparison of Two Kits Using RFLP and qPCR
Shammaa, Dina
Bazarbachi, Ali
Halas, Hussein
Greige, Layal
Mahfouz, Rami
GENETIC TESTING AND MOLECULAR BIOMARKERS, 2010, 14 (01) : 13 - 15
[16] The role of Janus Kinase 2 V617F mutation in extramedullary hematopoiesis of the spleen in neoplastic myeloid disorders
Hsieh, Pin-Pen
Olsen, Randy J.
O'Malley, Dennis P.
Konoplev, Sergej N.
Hussong, Jerry W.
Dunphy, Cherie H.
Perkins, Sherrie L.
Cheng, Liang
Lin, Pei
Chang, Chung-Che
MODERN PATHOLOGY, 2007, 20 (09) : 929 - 935
[17] JAK2 V617F prevalence in Brazilian patients with polycythemia vera, idiopathic myelofibrosis and essential thrombocythemia
Reis Monte-Mor, Barbara da Costa
da Cunha, Anderson Ferreira
Barbosa Pagnano, Katia Borgia
Saad, Sara Terezinha
Lorand-Metze, Irene
Costa, Fernando Ferreira
GENETICS AND MOLECULAR BIOLOGY, 2007, 30 (02) : 336 - 338
[18] Derivative (1)t(1;19)(p13;p13) in the setting of myelofibrosis with JAK2 V617F
Staropoli, John F.
Wadleigh, Martha
Dal Cin, Paola
CANCER GENETICS AND CYTOGENETICS, 2009, 191 (02) : 109 - 110
[19] Essential thrombocythemia. Contribution of the V617F JAK2 mutation to the pathophysiology, diagnosis and outcome
Briere, Jean
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE, 2007, 191 (03): : 535 - 548
[20] Evaluation of V617F mutation of JAK2 in negative chromosome Philadelphia chronic myeloproliferative disorders
Remacha, Angel F.
Puget, Guiomar
Nomdedeu, Josep F.
Estivill, Camino
Pilar Sarda, M.
Canals, Carme
MEDICINA CLINICA, 2006, 127 (16): : 601 - 604

← 1 2 3 4 5 →