Cutaneous Myelofibrosis With JAK2 V617F Mutation: Metastasis, Not Merely Extramedullary Hematopoiesis!

被引：11

作者：

Fraga, Garth R. ^{[1
]}

Caughron, Samuel K. ^{[2
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA

[2] MAWD Pathol Grp, Kansas City, MO USA

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2010年 / 32卷 / 07期

关键词：

myelofibrosis; extramedullary hematopoiesis; metastasis; JAK2; leukemia; MYELOID METAPLASIA; IDIOPATHIC MYELOFIBROSIS; SKIN; MANIFESTATION; PATHOGENESIS;

D O I：

10.1097/DAD.0b013e3181d3ca2f

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm. There are 31 reported cases of cutaneous involvement by PMF, most of which have been described as "extramedullary hematopoiesis.'' We report a new case of cutaneous involvement by PMF and demonstrate mutation of the Janus kinase 2 gene in the cutaneous lesions. Extramedullary myelofibrosis is best considered a metastatic phenomenon. Reporting such cases as extramedullary hematopoiesis may cause confusion with reactive forms of extramedullary hematopoiesis.

引用

页码：727 / 730

页数：4

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