Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C

被引：12

作者：

Nagaoki, Yuko ^{[1
]}

Imamura, Michio ^{[1
]}

Kawakami, Yoshiiku ^{[1
]}

Kan, Hiromi ^{[1
]}

Fujino, Hatsue ^{[1
]}

Fukuhara, Takayuki ^{[1
]}

Kobayashi, Tomoki ^{[1
]}

Ono, Atsushi ^{[1
]}

Nakahara, Takashi ^{[1
]}

Naeshiro, Noriaki ^{[1
]}

Urabe, Ayako ^{[1
]}

Yokoyama, Satoe ^{[1
]}

Miyaki, Daisuke ^{[1
]}

Murakami, Eisuke ^{[1
]}

Kawaoka, Tomokazu ^{[1
]}

Tsuge, Masataka ^{[1
]}

Hiramatsu, Akira ^{[1
]}

Aikata, Hiroshi ^{[1
]}

Takahashi, Shoichi ^{[1
]}

Hayes, C. Nelson ^{[1
]}

Ochi, Hidenori ^{[2
]}

Chayama, Kazuaki ^{[1
,2
]}

机构：

[1] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Gastroenterol & Metab, Hiroshima 7348551, Japan

[2] Inst Phys & Chem Res RIKEN, Ctr Genom Med, Lab Digest Dis, Hiroshima, Japan

来源：

HEPATOLOGY RESEARCH | 2014年 / 44卷 / 14期

关键词：

chronic hepatitis C; inteferon lambda 4; rapid virological response; sustained virological response; telaprevir; GENOME-WIDE ASSOCIATION; GENOTYPE; INFECTION; HEPATOCELLULAR-CARCINOMA; ITPA POLYMORPHISM; GENETIC-VARIATION; VIRAL RESPONSE; IL28B; HCV; PEGINTERFERON; VIRUS;

D O I：

10.1111/hepr.12336

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AimThe predictive value of the recently identified interferon- (IFNL)4 polymorphism on the outcome of telaprevir (TVR), pegylated interferon (PEG IFN) plus ribavirin (RBV) combination therapy for chronic hepatitis C is unknown. MethodsWe assessed predictive factors for sustained virological response (SVR) for TVR, PEG IFN plus RBV combination therapy in 283 genotype 1 chronic hepatitis C patients. IFNL4 polymorphism ss469415590 was analyzed by Invader assay. ResultsSVR rates for patients with IFNL4 TT/TT genotype were significantly higher than for those with the IFNL4 TT/G or G/G genotypes (93% and 59%, respectively, P<0.0001). In a multivariate regression analysis, prior treatment history (treatment-naive patients or patients who relapsed during prior treatment) (odds ratio [OR], 2.385; P=0.028), rapid virological response (OR, 6.800; P<0.0001) and ss469415590 TT/TT genotype (OR, 8.064; P<0.0001) were identified as significant independent predictors for SVR. In patients with IFNL4 TT/G or G/G genotypes, SVR rates for non-RVR patients were significantly lower than RVR patients (22% and 75%, respectively, P<0.0001). ConclusionAnalysis of IFNL4 polymorphism is a valuable predictor in patients receiving TVR triple therapy.

引用

页码：E447 / E454

页数：8

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