Toll-like receptor-dependent lipid body formation in macrophage foam cell formation

被引：28
作者：
Nicolaou, Giovanna [1 ]
Erridge, Clett [1 ]
机构：
[1] Univ Leicester, Glenfield Gen Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England
来源：
CURRENT OPINION IN LIPIDOLOGY | 2010年 / 21卷 / 05期
关键词：
atherosclerosis; lipid bodies; lipid droplets; macrophage foam cells; Toll-like receptors; CASSETTE TRANSPORTER A1; CHLAMYDIA-PNEUMONIAE; MYCOBACTERIUM-LEPRAE; MURINE MACROPHAGES; PPAR-GAMMA; IN-VIVO; EXPRESSION; ALPHA; AGONISTS; ACCUMULATION;
D O I：
10.1097/MOL.0b013e32833cacd5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TLR stimulation promotes the accumulation of lipid bodies in macrophages and consequently foam cell formation. The pathways responsible for these processes may constitute novel therapeutic targets for atherosclerosis.
引用
收藏
页码：427 / 433
页数：7
相关论文
共 51 条
  • [1] Mycobacterium bovis Bacillus Calmette-Guerin Infection Induces TLR2-Dependent Peroxisome Proliferator-Activated Receptor γ Expression and Activation: Functions in Inflammation, Lipid Metabolism, and Pathogenesis
    Almeida, Patricia E.
    Silva, Adriana R.
    Maya-Monteiro, Clarissa M.
    Torocsik, Daniel
    D'Avila, Heloisa
    Dezsoe, Balazs
    Magalhaes, Kelly G.
    Castro-Faria-Neto, Hugo C.
    Nagy, Laszlo
    Bozza, Patricia T.
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (02) : 1337 - 1345
  • [2] EVIDENCE THAT THE DEATH OF MACROPHAGE FOAM CELLS CONTRIBUTES TO THE LIPID CORE OF ATHEROMA
    BALL, RY
    STOWERS, EC
    BURTON, JH
    CARY, NRB
    SKEPPER, JN
    MITCHINSON, MJ
    [J]. ATHEROSCLEROSIS, 1995, 114 (01) : 45 - 54
  • [3] Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells
    Baranova, I
    Vishnyakova, T
    Bocharov, A
    Chen, ZG
    Remaley, AT
    Stonik, J
    Eggerman, TL
    Patterson, AP
    [J]. INFECTION AND IMMUNITY, 2002, 70 (06) : 2995 - 3003
  • [4] TIP47, a Lipid Cargo Protein Involved in Macrophage Triglyceride Metabolism
    Buers, Insa
    Robenek, Horst
    Lorkowski, Stefan
    Nitschke, Yvonne
    Severs, Nicholas J.
    Hofnagel, Oliver
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (05) : 767 - U323
  • [5] Chlamydia pneumonia-induced macrophage foam cell formation is mediated by toll-like receptor 2
    Cao, Fei
    Castrillo, Antonio
    Tontonoz, Peter
    Re, Fabio
    Byrne, Gerald I.
    [J]. INFECTION AND IMMUNITY, 2007, 75 (02) : 753 - 759
  • [6] Crosstalk between LXR and Toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism
    Castrillo, A
    Joseph, SB
    Vaidya, SA
    Haberland, M
    Fogelman, AM
    Cheng, GH
    Tontonoz, P
    [J]. MOLECULAR CELL, 2003, 12 (04) : 805 - 816
  • [7] ROS and NF-κB but not LXR mediate IL-1β signaling for the downregulation of ATP-binding cassette transporter A1
    Chen, Min
    Li, Wenjing
    Wang, Nanping
    Zhu, Yi
    Wang, Xian
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2007, 292 (04): : C1493 - C1501
  • [8] Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation
    Chen, Shuang
    Sorrentino, Rosalinda
    Shimada, Kenichi
    Bulut, Yonca
    Doherty, Terence M.
    Crother, Timothy R.
    Arditi, Moshe
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 181 (10) : 7186 - 7193
  • [9] Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages
    Chinetti-Gbaguidi, G.
    Staels, B.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2009, 1791 (06): : 486 - 493
  • [10] Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4-Dependent Fluid Phase Uptake
    Choi, Soo-Ho
    Harkewicz, Richard
    Lee, Jee Hyun
    Boullier, Agnes
    Almazan, Felicidad
    Li, Andrew C.
    Witztum, Joseph L.
    Bae, Yun Soo
    Miller, Yury I.
    [J]. CIRCULATION RESEARCH, 2009, 104 (12) : 1355 - U215
123456