Reduced whole-body fat oxidation in women and in the elderly

被引:55
作者
Levadoux, E
Morio, B
Montaurier, C
Puissant, V
Boirie, Y
Fellmann, N
Picard, B
Rousset, P
Beaufrere, B
Ritz, P
机构
[1] Human Nutr Lab, Clermont Ferrand, France
[2] Physiol & Exercise Biol Lab, Clermont Ferrand, France
[3] INRA, F-63122 St Genes Champanelle, France
[4] Human Nutr Res Ctr, Auvergne, France
关键词
fat oxidation; indirect calorimetry; aging; sex;
D O I
10.1038/sj.ijo.0801530
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: To test the hypothesis that the increase in fat mass observed with aging might be related to a decrease in whole-body fat oxidation. SUBJECTS AND MEASUREMENTS: Forty volunteers had measurements of sleeping and 24 h substrate oxidation in calorimetric chambers, body composition with the O-18 dilution technique, VO2max, and fiber composition analysis from a biopsy of vastus lateralis. They were divided into 10 young women, 10 young men, 10 elderly women and 10 elderly men. RESULTS: Sleeping fat oxidation and 24 h fat oxidation were lower in women than in men and in elderly than in young participants. Sleeping fat oxidation was correlated to fat-free mass and energy balance (multivariate analysis). Twenty four hour fat oxidation was correlated to total energy expenditure and energy balance (multivariate analysis). After adjustment for differences in these factors, sleeping and 24 h fat oxidation were no longer different between age and sex groups. None of the parameters of macronutrient metabolism was correlated with muscle fiber composition. CONCLUSION: Our data suggest that fat oxidation is lower in elderly subjects. This difference could favour fat mass gain if fat intake is not adequately reduced. Differences in fat-free mass and in total energy expenditure appear to participate in the reduction in fat oxidation.
引用
收藏
页码:39 / 44
页数:6
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