Oral probiotics in coronavirus disease 2019: connecting the gut-lung axis to viral pathogenesis, inflammation, secondary infection and clinical trials

被引：63

作者：

Baindara, P. ^{[1
]}

Chakraborty, R. ^{[2
]}

Holliday, Z. M. ^{[3
]}

Mandal, S. M. ^{[4
]}

Schrum, A. G. ^{[1
,5
,6
]}

机构：

[1] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65211 USA

[2] North Bengal Univ, Dept Biotechnol, Darjeeling, India

[3] Univ Missouri, Sch Med, Pulm Dis, Crit Care Med, Columbia, MO 65211 USA

[4] Indian Inst Technol Kharagpur, Cent Res Facil, Kharagpur, India

[5] Univ Missouri, Sch Med, Dept Surg, Columbia, MO 65211 USA

[6] Univ Missouri, Coll Engn, Dept Biomed Biol & Chem Engn, Columbia, MO 65211 USA

来源：

NEW MICROBES AND NEW INFECTIONS | 2021年 / 40卷

基金：

美国国家卫生研究院;

关键词：

Coronavirus disease 2019; gut-lung axis; gut microbiome; probiotics; secondary infection; severe acute respiratory syndrome coronavirus 2; LACTOBACILLUS-RHAMNOSUS GG; VENTILATOR-ASSOCIATED PNEUMONIA; LACTIC-ACID BACTERIA; RHINOVIRUS; INFLUENZA; INHIBITION; SUPPLEMENTATION; CONSUMPTION; SARS-COV-2; IMMUNITY;

D O I：

10.1016/j.nmni.2021.100837

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Defined as helpful live bacteria that can provide medical advantages to the host when administered in tolerable amounts, oral probiotics might be worth considering as a possible preventive or therapeutic modality to mitigate coronavirus disease 2019 (COVID-19) symptom severity. This hypothesis stems from an emerging understanding of the gut-lung axis wherein probiotic microbial species in the digestive tract can influence systemic immunity, lung immunity, and possibly viral pathogenesis and secondary infection co-morbidities. We review the principles underlying the gut-lung axis, examples of probiotic-associated antiviral activities, and current clinical trials in COVID-19 based on oral probiotics. (C) 2021 The Authors. Published by Elsevier Ltd.

引用

页数：7

共 70 条

[31] Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial [J].

Luoto, Raakel ;

Ruuskanen, Olli ;

Waris, Matti ;

Kalliomaki, Marko ;

Salminen, Seppo ;

Isolauri, Erika .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2014, 133 (02) :405-413

[32] Serial Analysis of the Gut and Respiratory Microbiome in Cystic Fibrosis in Infancy: Interaction between Intestinal and Respiratory Tracts and Impact of Nutritional Exposures [J].

Madan, J. C. ;

Koestler, D. C. ;

Stanton, B. A. ;

Davidson, L. ;

Moulton, L. A. ;

Housman, M. L. ;

Moore, J. H. ;

Guill, M. F. ;

Morrison, H. G. ;

Sogin, M. L. ;

Hampton, T. H. ;

Karagas, M. R. ;

Palumbo, P. E. ;

Foster, J. A. ;

Hibberd, P. L. ;

O'Toole, G. A. .

MBIO, 2012, 3 (04)

[33] Antiviral effects of nisin, lysozyme, lactoferrin and their mixtures against bovine viral diarrhoea virus [J].

Malaczewska, Joanna ;

Kaczorek-Lukowska, Edyta ;

Wojcik, Roman ;

Siwicki, Andrzej Krzysztof .

BMC VETERINARY RESEARCH, 2019, 15 (01)

[34] Fusion Protein Targeted Antiviral Peptides: Fragment-Based Drug Design (FBDD) Guided Rational Design of Dipeptides Against SARS-CoV-2 [J].

Manna, Sounik ;

Chowdhury, Trinath ;

Baindara, Piyush ;

Mandal, Santi M. .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2020, 21 (10) :938-947

[35] Molecular pathogenesis of secondary bacterial infection associated to viral infections including SARS-CoV-2 [J].

Manna, Sounik ;

Baindara, Piyush ;

Mandal, Santi M. .

JOURNAL OF INFECTION AND PUBLIC HEALTH, 2020, 13 (10) :1397-1404

[36] Probiotic Prophylaxis of Ventilator-associated Pneumonia A Blinded, Randomized, Controlled Trial [J].

Morrow, Lee E. ;

Kollef, Marin H. ;

Casale, Thomas B. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (08) :1058-1064

[37] Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces [J].

Oh, Nam Su ;

Joung, Jae Yeon ;

Lee, Ji Young ;

Kim, Younghoon .

PLOS ONE, 2018, 13 (02)

[38] COVID-19 in gastroenterology: a clinical perspective [J].

Ong, John ;

Young, Barnaby Edward ;

Ong, Sharon .

GUT, 2020, 69 (06) :1144-+

[39] Crossing barriers: infections of the lung and the gut [J].

Openshaw, P. J. .

MUCOSAL IMMUNOLOGY, 2009, 2 (02) :100-102

[40]

Palomar Martin M., 2017, Journal of Nutrition & Intermediary Metabolism, V8, P29, DOI 10.1016/j.jnim.2017.06.001

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