Oral probiotics in coronavirus disease 2019: connecting the gut-lung axis to viral pathogenesis, inflammation, secondary infection and clinical trials

被引：63

作者：

Baindara, P. ^{[1
]}

Chakraborty, R. ^{[2
]}

Holliday, Z. M. ^{[3
]}

Mandal, S. M. ^{[4
]}

Schrum, A. G. ^{[1
,5
,6
]}

机构：

[1] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65211 USA

[2] North Bengal Univ, Dept Biotechnol, Darjeeling, India

[3] Univ Missouri, Sch Med, Pulm Dis, Crit Care Med, Columbia, MO 65211 USA

[4] Indian Inst Technol Kharagpur, Cent Res Facil, Kharagpur, India

[5] Univ Missouri, Sch Med, Dept Surg, Columbia, MO 65211 USA

[6] Univ Missouri, Coll Engn, Dept Biomed Biol & Chem Engn, Columbia, MO 65211 USA

来源：

NEW MICROBES AND NEW INFECTIONS | 2021年 / 40卷

基金：

美国国家卫生研究院;

关键词：

Coronavirus disease 2019; gut-lung axis; gut microbiome; probiotics; secondary infection; severe acute respiratory syndrome coronavirus 2; LACTOBACILLUS-RHAMNOSUS GG; VENTILATOR-ASSOCIATED PNEUMONIA; LACTIC-ACID BACTERIA; RHINOVIRUS; INFLUENZA; INHIBITION; SUPPLEMENTATION; CONSUMPTION; SARS-COV-2; IMMUNITY;

D O I：

10.1016/j.nmni.2021.100837

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Defined as helpful live bacteria that can provide medical advantages to the host when administered in tolerable amounts, oral probiotics might be worth considering as a possible preventive or therapeutic modality to mitigate coronavirus disease 2019 (COVID-19) symptom severity. This hypothesis stems from an emerging understanding of the gut-lung axis wherein probiotic microbial species in the digestive tract can influence systemic immunity, lung immunity, and possibly viral pathogenesis and secondary infection co-morbidities. We review the principles underlying the gut-lung axis, examples of probiotic-associated antiviral activities, and current clinical trials in COVID-19 based on oral probiotics. (C) 2021 The Authors. Published by Elsevier Ltd.

引用

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