Light-responsive polyelectrolyte/gold nanoparticle microcapsules

被引：329

作者：

Angelatos, AS ^{[1
]}

Radt, B ^{[1
]}

Caruso, F ^{[1
]}

机构：

[1] Univ Melbourne, Ctr Nanosci & Nanotechnol, Dept Chem & Biomol Engn, Parkville, Vic 3010, Australia

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2005年 / 109卷 / 07期

关键词：

D O I：

10.1021/jp045070x

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report the preparation and characterization of light-responsive delivery vehicles, microcapsules composed of multiple polyelectrolyte layers and light-absorbing gold nanoparticles. The nanostructured capsules were loaded with macromolecules (fluorescein isothiocyanate-labeled dextran) by exploiting the pH-dependence of the shell permeability, and the encapsulated material was released on demand upon irradiation with short (10 ns) laser pulses in the near-infrared (1064 nm). In addition, the polyelectrolyte multilayer shell was modified with lipids (dilauroylphosphatidylethanolamine) and then functionalized with ligands (monoclonal immunoglobulin G antibodies) for the purposes of enhanced stability and targeted delivery, respectively. We anticipate that these capsules will find application in a range of areas where controlled delivery is desirable.

引用

页码：3071 / 3076

页数：6

共 33 条

[1] Laser-induced reshaping of metallodielectric nanoshells under femtosecond and nanosecond plasmon resonant illumination [J].