Developmental fate of ovoid oocytes

被引:50
作者
Ebner, T. [1 ]
Shebl, O. [1 ]
Moser, M. [1 ]
Sommergruber, M. [1 ]
Tews, G. [1 ]
机构
[1] Landes Frauen & Kinderklin, IVF Unit, A-4020 Linz, Austria
关键词
blastocyst formation; compaction; ovoid shape; roundness index; zona pellucida;
D O I
10.1093/humrep/dem280
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: Irregularities in composition, thickness and/or color of the zona pellucida may impair optimal function and result in reduced outcome. Anomalies of oocyte shape have not been investigated in detail in this respect. METHODS: Therefore, all patients attending our clinic within a period of 1 year were screened for the presence of ovoid gametes and the corresponding developmental potential was evaluated. For all elongated gametes, a roundness index (RI; length divided by width) was calculated in order to quantify shape. RESULTS: RI did not affect fertilizability (P > 0.05). The degree of dysmorphism was found to be related to cleavage pattern. The more ovoid a gamete was, the higher was the risk of the corresponding zygote not cleaving like a tetrahedron (P < 0.01). Abnormal cleavage (a rather flat array of blastomeres) was associated with delayed compaction (P < 0.01) and blastocyst formation (P < 0.001). The quality of blastocysts was not affected at any stage in ovoid concepti (P > 0.05). CONCLUSIONS: Ovoid oocytes with abnormal cleavage pattern show delayed preimplantation development, probably due to a reduced number of cell-to-cell contacts.
引用
收藏
页码:62 / 66
页数:5
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