Regioselective Anomeric O-Benzyl Deprotection in Carbohydrates

被引：3

作者：

Sridhar, Perali Ramu ^{[1
]}

Anjaneyulu, Bandi ^{[1
]}

Rao, Boddu Umamaheswara ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Gachibowli, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 41期

关键词：

Carbohydrates; Glycosides; Hemiacetals; Hydrogenolysis; Protecting groups; DEBENZYLATION; DERIVATIVES; EFFICIENT; REMOVAL; ETHERS;

D O I：

10.1002/ejoc.202101033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regioselective hydrogenolysis of the anomeric benzyl group is reported. The reaction involves selective acetolysis of benzyl acetals of various mono- and di-saccharides using 10 % Pd/C under hydrogen atmosphere in the presence of Na2CO3. The generality of the methodology is evaluated by applying it to a number of perbenzylated/orthogonally protected benzyl glycosides.

引用

页码：5665 / 5668

页数：4

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