Capacitive Sensing for Non-Invasive Breathing and Heart Monitoring in Non-Restrained, Non-Sedated Laboratory Mice

被引:20
作者
Gonzalez-Sanchez, Carlos [1 ]
Fraile, Juan-Carlos [2 ]
Perez-Turiel, Javier [2 ]
Damm, Ellen [3 ,4 ]
Schneider, Jochen G. [3 ,4 ]
Zimmermann, Heiko [1 ,5 ]
Schmitt, Daniel [1 ]
Ihmig, Frank R. [1 ]
机构
[1] Fraunhofer Inst Biomed Tech IBMT, D-66280 Sulzbach, Germany
[2] Univ Valladolid, ITAP, Paseo Cauce 59, E-47011 Valladolid, Spain
[3] Univ Luxembourg, Luxembourg Ctr Syst Biomed, L-4362 Esch Sur Alzette, Luxembourg
[4] Univ Saarland, Med Ctr, Internal Med 2, D-66421 Homburg, Germany
[5] Univ Saarland, Mol & Cellular Biotechnol Nanotechnol, D-66123 Saarbrucken, Germany
关键词
non-invasive sensor; capacitive sensors; physiological signals in mice; stress in mice; RATE-VARIABILITY; STRESS; TRANSPORTATION; ANIMALS; SENSOR;
D O I
10.3390/s16071052
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Animal testing plays a vital role in biomedical research. Stress reduction is important for improving research results and increasing the welfare and the quality of life of laboratory animals. To estimate stress we believe it is of great importance to develop non-invasive techniques for monitoring physiological signals during the transport of laboratory animals, thereby allowing the gathering of information on the transport conditions, and, eventually, the improvement of these conditions. Here, we study the suitability of commercially available electric potential integrated circuit (EPIC) sensors, using both contact and contactless techniques, for monitoring the heart rate and breathing rate of non-restrained, non-sedated laboratory mice. The design has been tested under different scenarios with the aim of checking the plausibility of performing contactless capture of mouse heart activity (ideally with an electrocardiogram). First experimental results are shown.
引用
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页数:16
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