Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States

被引：73

作者：

Matias, Wilfredo R. ^{[1
,2
,3
,4
]}

Koshy, Jacob M. ^{[3
,5
]}

Nagami, Ellen H. ^{[1
,2
,3
]}

Kovac, Victor ^{[1
,2
,3
]}

Moeng, Letumile R. ^{[3
,5
]}

Shenoy, Erica S. ^{[1
,3
]}

Hooper, David C. ^{[1
,3
]}

Madoff, Lawrence C. ^{[6
,7
]}

Barshak, Miriam B. ^{[1
,3
]}

Johnson, Jennifer A. ^{[2
,3
]}

Rowley, Christopher F. ^{[3
,5
]}

Julg, Boris ^{[1
,3
,8
]}

Hohmann, Elizabeth L. ^{[1
,3
]}

Lazarus, Jacob E. ^{[1
,3
]}

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[2] Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Mass Gen Ctr Global Hlth, Boston, MA USA

[5] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[6] Massachusetts Dept Publ Hlth, Boston, MA USA

[7] Univ Massachusetts, Chan Mod Sch, Worcester, MA 01605 USA

[8] Flagon Inst MGH MIT & Harvard, Cambridge, MA USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2022年 / 9卷 / 08期

基金：

美国国家卫生研究院;

关键词：

antiviral; monkeypox; smallpox; tecovirimat;

D O I：

10.1093/ofid/ofac377

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.

引用

页数：4

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