On-Column Preconcentration of Anti-Inflammatory Drugs in River Water by Anion-Selective Exhaustive Injection-Sweeping-MEKC

被引：14

作者：

Maijo, Irene ^{[1
]}

Borrull, Francesc ^{[1
]}

Aguilar, Carme ^{[1
]}

Calull, Marta ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Dept Analyt Chem & Organ Chem, Tarragona 43007, Spain

来源：

CHROMATOGRAPHIA | 2011年 / 73卷 / 1-2期

关键词：

Micellar electrokinetic capillary chromatography; Anion-selective exhaustive injection; Sweeping; River water; Non-steroidal anti-inflammatory drugs; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; SUPPRESSED ELECTROOSMOTIC FLOW; AMPLIFIED SAMPLE INJECTION; LYSERGIC-ACID DIETHYLAMIDE; CAPILLARY-ELECTROPHORESIS; SENSITIVITY ENHANCEMENT; STACKING; DICLOFENAC; STRATEGIES;

D O I：

10.1007/s10337-010-1817-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A high-sensitivity on-column preconcentration method, anion selective exhaustive injection (ASEI)-sweeping in micellar electrokinetic capillary chromatography (MEKC) has been developed for the analysis of non-steroidal anti-inflammatory drugs (NSAIDs): diclofenac sodium, ibuprofen, fenoprofen, naproxen, and ketoprofen in water samples. To achieve the best results of the ASEI-sweeping-MEKC method, conditions which affected preconcentration were examined, including the sodium dodecyl sulfate concentration, composition of the sample matrix, composition and injection length of the water plug, the concentration and the injection length of the high-conductivity buffer, and finally the sample injection time. Under the optimum stacking conditions the method was validated for the determination of the studied NSAIDs in river water samples with limits of detection ranging between 29 and 58 ng mL(-1), and without any previous sample pretreatment.

引用

页码：83 / 91

页数：9

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