Monocyte Fate in Atherosclerosis

被引：171

作者：

Hilgendorf, Ingo ^{[1
]}

Swirski, Filip K. ^{[2
]}

Robbins, Clinton S. ^{[3
,4
]}

机构：

[1] Univ Freiburg, Ctr Heart, Dept Cardiol & Angiol, D-79106 Freiburg, Germany

[2] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[3] Univ Toronto, Toronto Gen Res Inst, Peter Munk Cardiac Ctr, Dept Lab Med, Toronto, ON M5G 1L7, Canada

[4] Univ Toronto, Toronto Gen Res Inst, Peter Munk Cardiac Ctr, Dept Pathobiol & Immunol, Toronto, ON M5G 1L7, Canada

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2015年 / 35卷 / 02期

基金：

加拿大健康研究院;

关键词：

atherosclerosis; cardiovascular disease; inflammation; macrophage; monocyte; ELEVATION MYOCARDIAL-INFARCTION; HEMATOPOIETIC PROGENITOR CELLS; CLASS-A OVEREXPRESSION; MARROW-DERIVED CELLS; BONE-MARROW; SCAVENGER RECEPTORS; MACROPHAGE ACCUMULATION; LY-6C(HIGH) MONOCYTES; CIRCULATING MONOCYTES; ENDOTHELIAL-CELLS;

D O I：

10.1161/ATVBAHA.114.303565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Monocytes and their descendant macrophages are essential to the development and exacerbation of atherosclerosis, a lipid-driven inflammatory disease. Lipid-laden macrophages, known as foam cells, reside in early lesions and advanced atheromata. Our understanding of how monocytes accumulate in the growing lesion, differentiate, ingest lipids, and contribute to disease has advanced substantially over the last several years. These cells' remarkable phenotypic and functional complexity is a therapeutic opportunity: in the future, treatment and prevention of cardiovascular disease and its complications may involve specific targeting of atherogenic monocytes/macrophages and their products.

引用

页码：272 / 279

页数：8

共 110 条

[1] CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE-/- mice [J].

Aiello, Robert J. ;

Perry, Bret D. ;

Bourassa, Patricia-Ann ;

Robertson, Andrew ;

Weng, Weifan ;

Knight, Delvin R. ;

Smith, Andrew H. ;

Frederick, Kosea S. ;

Kalgutkar, Amit ;

Gladue, Ronald P. .

ATHEROSCLEROSIS, 2010, 208 (02) :370-375

[2] P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice [J].

An, Guangyu ;

Wang, Huan ;

Tang, Rong ;

Yago, Tadayuki ;

McDaniel, J. Michael ;

McGee, Samuel ;

Huo, Yuqing ;

Xia, Lijun .

CIRCULATION, 2008, 117 (25) :3227-3237

[3] Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior [J].

Auffray, Cedric ;

Fogg, Darin ;

Garfa, Meriem ;

Elain, Gaelle ;

Join-Lambert, Olivier ;

Kayal, Samer ;

Sarnacki, Sabine ;

Cumano, Ana ;

Lauvau, Gregoire ;

Geissmann, Frederic .

SCIENCE, 2007, 317 (5838) :666-670

[4]

AVERILL LE, 1989, AM J PATHOL, V135, P369

[5] Targeted anti-inflammatory systemic therapy for restenosis: The Biorest Liposomal Alendronate with Stenting sTudy (BLAST)-a double blind, randomized clinical trial [J].

Banai, Shmuel ;

Finkelstein, Ariel ;

Almagor, Yaron ;

Assali, Abid ;

Hasin, Yonathan ;

Rosenschein, Uri ;

Apruzzese, Patricia ;

Lansky, Alexandra J. ;

Kume, Teruyoshi ;

Edelman, Elazer R. .

AMERICAN HEART JOURNAL, 2013, 165 (02) :234-+

[6] Elevated CD14++CD16- Monocytes Predict Cardiovascular Events [J].

Berg, Katarina E. ;

Ljungcrantz, Irena ;

Andersson, Linda ;

Bryngelsson, Carl ;

Hedblad, Bo ;

Fredrikson, Gunilla N. ;

Nilsson, Jan ;

Bjorkbacka, Harry .

CIRCULATION-CARDIOVASCULAR GENETICS, 2012, 5 (01) :122-131

[7] Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm [J].

Biswas, Subhra K. ;

Mantovani, Alberto .

NATURE IMMUNOLOGY, 2010, 11 (10) :889-896

[8] Statin effects beyond lipid lowering-are they clinically relevant? [J].

Bonetti, PO ;

Lerman, LO ;

Napoli, C ;

Lerman, A .

EUROPEAN HEART JOURNAL, 2003, 24 (03) :225-248

[9] Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis [J].

Boring, L ;

Gosling, J ;

Cleary, M ;

Charo, IF .

NATURE, 1998, 394 (6696) :894-897

[10] Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease [J].

Braun, Oscar O. ;

Johnell, Matilda ;

Varenhorst, Christoph ;

James, Stefan ;

Brandt, John T. ;

Jakubowski, Joseph A. ;

Winters, Kenneth J. ;

Wallentin, Lars ;

Erlinge, David ;

Siegbahn, Agneta .

THROMBOSIS AND HAEMOSTASIS, 2008, 100 (04) :626-633

← 1 2 3 4 5 6 7 8 9 10 →