DNA Methyltransferase Inhibitor Induced Fungal Biosynthetic Products: Diethylene Glycol Phthalate Ester Oligomers from the Marine-Derived Fungus Cochliobolus lunatus

被引：22

作者：

Chen, Min ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

Shao, Chang-Lun ^{[1
,2
]}

Chi, Zhen-Ming ^{[3
,4
]}

Wang, Chang-Yun ^{[1
,2
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China

[3] Ocean Univ China, UNESCO Chinese Ctr Marine Biotechnol, Qingdao 266003, Peoples R China

[4] Ocean Univ China, Key Lab Marine Genet & Gene Resource Exploitat, Minist Educ, Qingdao 266003, Peoples R China

来源：

MARINE BIOTECHNOLOGY | 2016年 / 18卷 / 03期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Marine fungus; Cochliobolus lunatus (TA26-46); Chemical epigenetic manipulation; DNA methyltransferase inhibitor; 5-Azacytidine; Diethyleneglycol phthalate ester oligomers; RESORCYLIC ACID LACTONES; ANTIVIRAL ACTIVITY; ANTIFUNGAL; ORIGIN; ASSAY;

D O I：

10.1007/s10126-016-9703-y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chemical epigenetic manipulation was applied to the marine-derived fungus Cochliobolus lunatus (TA26-46) with a DNA methyltransferase inhibitor resulting in the significant changes of the secondary metabolites. Cultivation of C. lunatus (TA26-46) with 5-azacytidine led to the isolation of seven new diethylene glycol phthalate esters, cochphthesters A -G (1-6, 10), along with four known analogues (7-9, 11). Their structures were determined by extensive NMR spectroscopic spectra as well as MS data. Compounds 2-6 and 8-11, characterized by the cross-polymerization of phthalate across diethylene glycol via ester bonds, represent the first example of naturally occurring phthalate ester oligomers.

引用

页码：409 / 417

页数：9

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