MicroRNA pathways in neural development and plasticity

被引：68

作者：

Vo, Ngan K. ^{[1
]}

Cambronne, Xiaolu A. ^{[1
]}

Goodman, Richard H. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2010年 / 20卷 / 04期

关键词：

SMALL RNAS; POSTTRANSCRIPTIONAL REGULATION; TRANSLATIONAL CONTROL; UBIQUITIN LIGASE; PROTEIN; COMPLEXES; MIR-124; PHOSPHORYLATION; MORPHOGENESIS; BIOGENESIS;

D O I：

10.1016/j.conb.2010.04.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MicroRNAs contribute significantly to the development, survival, function, and plasticity of neurons. They silence expression of target genes by reducing mRNA stability and translation. Production of microRNAs is controlled via developmental and environmental cues and these small molecules, in concert with classical transcriptional regulators, amplify changes in neuronal maturation, dendrite morphogenesis, and synaptogenesis. Neurons compartmentalize mRNAs and microRNAs within specific subcellular domains to facilitate control of local protein synthesis in response to neuronal stimuli and to modulate synaptic plasticity. This review addresses issues relevant to microRNA function in neurons, in particular, their ability to reinforce developmental decisions and promote synaptic plasticity.

引用

页码：457 / 465

页数：9

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