Carbon Monoxide in Renal Physiology, Pathogenesis and Treatment of Renal Disease

被引:3
作者
Liu, Qingquan [1 ]
Cheng, Anying [1 ]
Wang, Yiru [1 ]
Lv, Yongman [1 ]
Chen, Zhi [2 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Nephrol, Wuhan, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Geriatr, 1095 Jiefang Ave, Wuhan 430030, Peoples R China
关键词
Carbon monoxide; CO-releasing molecules; heme oxygenase; nephrotoxicity; renal ischemia; reperfu-sion injury; renal fibrosis; ISCHEMIA-REPERFUSION INJURY; OXYGENASE-1; GENE-EXPRESSION; PROTECTS RAT-KIDNEY; HEME OXYGENASE; NITRIC-OXIDE; TUBULOGLOMERULAR FEEDBACK; OXIDATIVE STRESS; TUBULAR CELLS; CISPLATIN; INDUCTION;
D O I
10.2174/1381612827666210706161207
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Carbon monoxide (CO) is one of the endogenous gaseous messengers or gasotransmitters, and is a paramount mediator in physiological and disease conditions. In this review, we focus on the functions of CO in normal and pathological renal physiology. We discuss endogenous renal CO production and signaling in the normal kidney, the characteristic of CO-releasing molecules (CORMs) modalities, and outline its regulatory functions in renal physiology. This article summarizes the mechanisms as well as the effect of CO in the evolving field of renal diseases. We predict numerous innovative CO applications forevolvingcutting-edge scholarly work in the future.
引用
收藏
页码:4253 / 4260
页数:8
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