The association of serum 25-OH vitamin D with asthma in Saudi adults

被引：8

作者：

Al-Daghri, Nasser M. ^{[1
,2
]}

Al-Attas, Omar S. ^{[1
,2
]}

Yakout, Sobhy M. ^{[1
,2
]}

Alnaami, Abdullah M. ^{[1
,2
]}

Wani, Kaiser ^{[1
,2
]}

Alokail, Majed S. ^{[1
,2
]}

机构：

[1] King Saud Univ, Biomarkers Res Program, Riyadh, Saudi Arabia

[2] King Saud Univ, Coll Sci, Biochem Dept, Prince Mutaib Chair Biomarkers Osteoporosis, POB 2455, Riyadh 11451, Saudi Arabia

来源：

MEDICINE | 2018年 / 97卷 / 36期

关键词：

Arab adults; asthma; hypovitaminosis D; vitamin D; D DEFICIENCY; D-RECEPTOR; CHILDHOOD; CATHELICIDIN; PREVALENCE; PREGNANCY; HEALTH; GENE;

D O I：

10.1097/MD.0000000000012286

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The study aimed to assess the differences and associations of serum 25(OH) D levels in Saudi adults with and without asthma. A total of 1070 Saudi adults aged 22 to 28 years (359 with known asthma and 711 matched nonasthmatic controls) were selected randomly from the Riyadh Cohort, Saudi Arabia. Serum 25(OH) D serum levels were measured. Asthma diagnosis was taken from questionnaires. In all participants, 359 (33.6%) were known asthmatic and 711 (66.5%) were nonasthmatic. The overall incidence of vitamin D deficiency (serum 25(OH) D <25 nmol/L) was 29.6% in controls and 35.6% in asthma group (P=.01). The asthma group have a significantly lower serum 25(OH) D than the control group (P=.01) but lost significance after adjusting for age, body mass index (BMI), and sex. Nonasthmatic and asthmatic females had a higher incidence of vitamin D deficiency (33% and 46%) than nonasthmatic and asthmatic males (17% and 33%). Vitamin D deficiency is significantly high among Saudi adults with asthma, but more so among women. Whether vitamin D deficiency exacerbates asthma attack remains to be proven in this population.

引用

页数：5

共 38 条

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