Electroacupuncture suppresses the pain and pain-related anxiety of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC

被引：26

作者：

Du, Junying ^{[1
]}

Fang, Junfan ^{[1
]}

Xu, Zitong ^{[1
]}

Xiang, Xuaner ^{[1
]}

Wang, Sisi ^{[1
]}

Sun, Haiju ^{[1
]}

Shao, Xiaomei ^{[1
]}

Jiang, Yongliang ^{[1
]}

Liu, Boyi ^{[1
]}

Fang, Jianqiao ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, Clin Med Coll 3, Dept Neurobiol & Acupuncture Res, Key Lab Acupuncture & Neurol Zhejiang Prov, Hangzhou 310053, Zhejiang, Peoples R China

来源：

BRAIN RESEARCH | 2020年 / 1733卷

基金：

中国国家自然科学基金;

关键词：

Electroacupuncture; Pain; Pain-related anxiety-like behavior; NPS/NPSR system; ACC; S RECEPTOR GENE; NEUROPEPTIDE-S; DEPRESSION; HYPERALGESIA; BEHAVIOR; AROUSAL;

D O I：

10.1016/j.brainres.2020.146719

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: The neuropeptide S/Neuropeptide S receptor (NPS/NPSR) system is involved in the regulation of anxiety in rodents. Chronic inflammation can induce anxiety. Our lab has observed that electroacupuncture (EA) has a beneficial effect on chronic inflammatory pain and pain-related anxiety; however, the mechanism should be further clarified. In the present study, we used an inflammatory pain model to investigate the role of the NPS/NPSR system in the anterior cingulate cortex (ACC) in the analgesic and antianxiety effects of EA. Results: In an inflammatory pain model, the paw withdrawal thresholds (PWTs) were decreased, pain-related anxiety-like behaviors were induced, and the ipsilateral protein expression of NPS and NPSR was decreased in the ACC. EA stimulation increased the PWTs, reduced pain-related anxiety-like behavior, and enhanced the ipsilateral protein expression of NPS and NPSR in the ACC. NPS microinjection increased the PWTs and decreased pain-related anxiety-like behaviors. Furthermore, an NPSR inhibitor combined with EA reversed the effect of EA on the PWTs and pain-related anxiety-like behaviors. Conclusions: Our results suggest that EA suppresses pain and pain-related anxiety-like behavior of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC.

引用

页数：10

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