Genetic dissection of glucocorticoid receptor function in mice

被引：153
|
作者：
Tronche, F [1 ]
Kellendonk, C [1 ]
Reichardt, HM [1 ]
Schütz, G [1 ]
机构：
[1] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0959-437X(98)80007-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Upon hormone binding, the activated glucocorticoid receptor (GR) functions as a transcription factor via different modes of action to control gene expression. Recent gene-targeting studies in mice provide new insight into the role of GR in vivo and are helping decipher the molecular mechanisms underlying its actions.
引用
收藏
页码：532 / 538
页数：7
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