Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan, China

被引：14

作者：

Liu, Qianyun ^{[1
,2
]}

Xiong, Qing ^{[1
,2
]}

Mei, Fanghua ^{[3
]}

Ma, Chengbao ^{[1
,2
]}

Zhang, Zhen ^{[1
,2
]}

Hu, Bing ^{[3
]}

Xu, Junqiang ^{[3
]}

Jiang, Yongzhong ^{[3
]}

Zhan, Faxian ^{[3
]}

Zhou, Suhua ^{[3
]}

Tao, Li ^{[4
]}

Chen, Xianying ^{[1
,2
]}

Guo, Ming ^{[1
,2
]}

Wang, Xin ^{[1
,2
]}

Fang, Yaohui ^{[5
]}

Shen, Shu ^{[5
]}

Liu, Yingle ^{[1
,2
]}

Liu, Fang ^{[1
,2
]}

Zhou, Li ^{[1
,2
]}

Xu, Ke ^{[1
,2
]}

Ke, Changwen ^{[6
]}

Deng, Fei ^{[5
]}

Cai, Kun ^{[3
]}

Yan, Huan ^{[1
,2
]}

Chen, Yu ^{[1
,2
]}

Lan, Ke ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Life Sci, Inst Vaccine Res, State Key Lab Virol, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, Wuhan 430072, Peoples R China

[3] Hubei Prov Ctr Dis Control & Prevent, Wuhan 430079, Peoples R China

[4] Wuhan Jiangan Dist Ctr Dis Control & Prevent, Wuhan 430000, Peoples R China

[5] Chinese Acad Sci, Natl Virus Resource Ctr, Wuhan Inst Virol, Wuhan 430071, Peoples R China

[6] Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Peoples R China

来源：

INNOVATION | 2022年 / 3卷 / 01期

关键词：

VACCINE;

D O I：

10.1016/j.xinn.2021.100181

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity, but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants. Here, we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan, the earliest known epicenter. SARS-CoV-2 immunoglobulin G (IgG) was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant. However, varying degrees of immune escape was observed on the other tested variants in a patient-specific manner, with individuals showing remarkably broad neutralization potency. The immune escape can be largely attributed to several critical spike mutations. These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants.

引用

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