Integrated functional nanocolloids covered with artificial cell membranes for biomedical applications

被引：90
作者：
Matsuno, Ryosuke [1 ,3 ,4 ]
Ishihara, Kazuhiko [1 ,2 ,3 ,4 ]
机构：
[1] Univ Tokyo, Dept Mat Engn, Bunkyo Ku, Tokyo 1138586, Japan
[2] Univ Tokyo, Sch Engn, Dept Bioengn, Bunkyo Ku, Tokyo 1138586, Japan
[3] Univ Tokyo, Ctr NanoBio Integrat, Bunkyo Ku, Tokyo 1138586, Japan
[4] Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol CREST, Chiyoda Ku, Tokyo 1020075, Japan
来源：
NANO TODAY | 2011年 / 6卷 / 01期
关键词：
Nanocolloids; Artificial cell membrane; Surface modification; 2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer; Protein adsorption; Cell adhesion; TRANSFER RADICAL POLYMERIZATION; BLOCK-COPOLYMER MICELLES; PHOSPHOLIPID POLYMER; QUANTUM-DOT; 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE; GENE DELIVERY; DRUG-DELIVERY; BIOCOMPATIBLE POLYMER; SILICA NANOPARTICLES; SURFACE MODIFICATION;
D O I：
10.1016/j.nantod.2010.12.009
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The functionality of nanocolloids used in biomedical applications are subject to strong interference arising from significant interactions with biological components such as proteins and cells. Among the known examples of surface treatment of nanocolloids, the construction of an artificial cell membrane structure based on phospholipid polymers has proven effective in preventing the occurrence of biological reactions at the surface. Furthermore, certain bioactive molecules can be immobilized on the surface of the phospholipid polymer platform to generate bioaffinity for other biomolecules. This review describes preparation and characterization of integrated functional nanocolloids covered by artificial cell membrane structures and their performance in biomedical applications. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：61 / 74
页数：14
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