MIF-173G/C polymorphism is associated with NMO disease severity

被引：4
作者：
Brill, Livnat [1 ,2 ,3 ]
Vaknin-Dembinskya, Adi [1 ,2 ,3 ]
Zveik, Omri [1 ,2 ,3 ]
Haham, Nitsan [1 ,2 ,3 ]
Miller, Keren [4 ]
Benedek, Gil [4 ]
机构：
[1] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Neurol, Fac Med, Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Hadassah Med Ctr, Lab Neuroimmunol, Fac Med, Jerusalem, Israel
[3] Hebrew Univ Jerusalem, Hadassah Med Ctr, Agnes Ginges Ctr Neurogenet, Fac Med, Jerusalem, Israel
[4] Hadassah Med Ctr, Dept Genet, Tissue Typing & Immunogenet Lab, Jerusalem, Israel
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 339卷
关键词：
Neuromyelitis optica; Macrophage migration inhibitory factor; Single nucleotide polymorphism; Expanded disability status score; Biomarker; Autoimmune; MIGRATION INHIBITORY FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CLASS-II CONSTRUCTS; NEUROMYELITIS-OPTICA; CLINICAL-FEATURES; CD74; EXPRESSION; MIF; PROMOTER; BINDING; GENE;
D O I：
10.1016/j.jneuroim.2019.577120
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Our knowledge about genetic factors that drive the worsening of neuromyelitis optica (NMO) is limited. Herein, we analyzed the macrophage migration inhibitory factor (MIF) -173G/C functional polymorphism in NMO patients and controls. Our data reveal that the frequency of the high-expression MIF genotypes (CC/GC) did not differ between the two groups. However, frequency of this genotypes was elevated in patients diagnosed with both optic neuritis and myelitis compared with patients that were diagnosed with only one symptom. Furthermore, patients carrying the CC/CG genotypes had significantly higher disability score. We conclude that MIF is associated with NMO severity rather than susceptibility.
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页数：4
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