Association of miR-181 cluster polymorphisms with systemic lupus erythematosus risk

被引:0
作者
Wang, Chunfang [1 ,2 ]
Wang, Rong [1 ]
Lei, Ming [1 ]
Lu, Yulan [1 ]
Pang, Xiaoxia [1 ]
Huang, Huatuo [1 ]
Wang, Junli [1 ]
Wei, Yesheng [1 ]
Lan, Yan [3 ]
Wei, Chuandong [4 ]
机构
[1] Youjiang Med Univ Nationalities, Affiliated Hosp, Dept Clin Lab, 18 Zhongshan Rd 2, Baise 533000, Guangxi, Peoples R China
[2] Jinan Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China
[3] Youjiang Med Univ Nationalities, Affiliated Hosp, Dept Dermatol, Baise 533000, Guangxi, Peoples R China
[4] Guilin Med Univ, Affiliated Hosp 2, Dept Clin Lab, Guilin 541199, Guangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
miR-181; gene; polymorphisms; systemic lupus erythematosus; IMMUNOGLOBULIN-SECRETING CELLS; ISCHEMIC-STROKE; EXPRESSION; PATHOGENESIS; MICRORNA; PROMOTER; AUTOIMMUNITY; DISEASE; REGION; BLOOD;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Systemic lupus erythematosus (SLE) is an autoimmune disease manifested by self-reactive antibodies due to failure of selection in both B and T lymphocytes. miR-181, expressed in hematopoietic cell lineage, has been proven to be an important modulator of B- and T-cell differentiation, maturation, and function. This study aimed to investigate association of three polymorphisms (rs16927589 T>C, rs77418916 A>T, and rs8108402 C>T) of the miR-181 cluster with risk of SLE in a Chinese population. In this study, 202 patients with SLE and 299 control subjects were included. miR-181 polymorphisms were discriminated by Snapshot SNP genotyping assay and DNA sequencing methods. It was found that T allele, TT, and TC genotypes, and the TT/CT vs. CC and CC/CT vs. Tr models of rs8108402 C>T polymorphism were associated with increased risk of SLE (T vs. C: adjusted OR=1.51, 95% CI: 1.13 similar to 2.00, P=0.005; TT vs. CC: adjusted OR=2.65, 95% CI: 1.18 similar to 5.98, P=0.019; TC vs. CC: adjusted 013=1.50, 95% CI, 103 similar to 219, P=0.033; TT/CT vs. CC: adjusted OR=1.61, 95% CI: 1.12 similar to 2.31, P=0.010; CC/CT vs. TT: adjusted 013=2.23, 95% CI: 1.01 similar to 4.93, P=0.048). Haplotype analysis showed that TAT haplotype was associated with increased risk of SLE (OR=1.48, 95% CI: 1.09 similar to 2.00, P=0.011), while TAC haplotype was associated with decreased risk of SLE (OR=0.68, 95% CI: 0.53 similar to 0.89, P=0.004). However, significant association between the other two polymorphisms and SLE risk was not observed. In conclusion, for the first time, it was found that rs8108402 C>T polymorphism is associated with increased risk of SLE, in a Chinese population.
引用
收藏
页码:9388 / 9395
页数:8
相关论文
共 32 条
[1]  
Al Morshedy S., 2017, MEDICINE, V96, pe6370, DOI [10.1097/MD.0000000000006370, DOI 10.1097/MD.0000000000006370]
[2]   INCREASED MULTICLONAL ANTIBODY-FORMING CELL-ACTIVITY IN THE PERIPHERAL-BLOOD OF PATIENTS WITH SLE [J].
BECKER, TM ;
LIZZIO, EF ;
MERCHANT, B ;
REEVES, JP ;
STEINBERG, AD .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1981, 66 (03) :293-303
[3]   Fine particulate air pollution and systemic autoimmune rheumatic disease in two Canadian provinces [J].
Bernatsky, Sasha ;
Smargiassi, Audrey ;
Barnabe, Cheryl ;
Svenson, Lawrence W. ;
Brand, Allan ;
Martin, Randall V. ;
Hudson, Marie ;
Clarke, Ann E. ;
Fortin, Paul R. ;
van Donkelaar, Aaron ;
Edworthy, Steven ;
Belisle, Patrick ;
Joseph, Lawrence .
ENVIRONMENTAL RESEARCH, 2016, 146 :85-91
[4]   INCREASED IMMUNOGLOBULIN-SECRETING CELLS IN THE BLOOD OF PATIENTS WITH ACTIVE SYSTEMIC LUPUS-ERYTHEMATOSUS [J].
BLAESE, RM ;
GRAYSON, J ;
STEINBERG, AD .
AMERICAN JOURNAL OF MEDICINE, 1980, 69 (03) :345-350
[5]   Aberrant expression of microRNA in polycythemia vera [J].
Bruchova, Hana ;
Merkerova, Michaela ;
Prchal, Josef T. .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (07) :1009-1016
[6]   Circulating MicroRNA Expression Profiles Associated With Systemic Lupus Erythematosus [J].
Carlsen, Anting Liu ;
Schetter, Aaron J. ;
Nielsen, Christoffer T. ;
Lood, Christian ;
Knudsen, Steen ;
Voss, Anne ;
Harris, Curtis C. ;
Hellmark, Thomas ;
Segelmark, Marten ;
Jacobsen, Soren ;
Bengtsson, Anders A. ;
Heegaard, Niels H. H. .
ARTHRITIS AND RHEUMATISM, 2013, 65 (05) :1324-1334
[7]   MicroRNAs modulate hematopoietic lineage differentiation [J].
Chen, CZ ;
Li, L ;
Lodish, HF ;
Bartel, DP .
SCIENCE, 2004, 303 (5654) :83-86
[8]   The role of microRNAs in the pathogenesis of autoimmune diseases [J].
Chen, Ji-Qing ;
Papp, Gabor ;
Szodoray, Peter ;
Zeher, Margit .
AUTOIMMUNITY REVIEWS, 2016, 15 (12) :1171-1180
[9]   Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes [J].
Dozmorov, Mikhail G. ;
Wren, Jonathan D. ;
Alarcon-Riquelme, Marta E. .
EPIGENETICS, 2014, 9 (02) :276-285
[10]   A genetic variant in the promoter region of miR-34b/c is associated with a reduced risk of colorectal cancer [J].
Gao, Lin-Bo ;
Li, Li-Juan ;
Pan, Xin-Min ;
Li, Zhao-Hui ;
Liang, Wei-Bo ;
Bai, Peng ;
Zhu, Yin-Hua ;
Zhang, Lin .
BIOLOGICAL CHEMISTRY, 2013, 394 (03) :415-420