An efficient synthesis of 2-diazo-2-(trimethylsilyl)ethanols and their application to pyrazole synthesis

被引：45

作者：

Hari, Yoshiyuki ^{[1
]}

Tsuchida, Susumu ^{[1
]}

Sone, Ryosuke ^{[1
]}

Aoyama, Toyohiko ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Nagoya, Aichi 4678603, Japan

来源：

SYNTHESIS-STUTTGART | 2007年 / 21期

关键词：

diazoalcohol; 2-diazo-2-(trimethylsilyl)ethanols; diazo(trimethylsilyl)methylmagnesium bromide; pyrazoles; trimethylsilyldiazomethane;

D O I：

10.1055/s-2007-990817

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of diazo(trimethylsilyl)methylmagnesium bromide with aldehydes or ketones gave 2-diazo-2-(trimethylsilyl)ethanols, which were applied to the synthesis of di- and trisubstituted pyrazoles via [3+2] cycloaddition reaction with ethyl propiolate or dimethyl acetylenedicarboxylate.

引用

页码：3371 / 3375

页数：5