Highly Enantioselective Synthesis of Tetrahydroquinolines via Cobalt(II)-Catalyzed Tandem 1,5-Hydride Transfer/Cyclization

被引：133

作者：

Cao, Weidi ^{[1
]}

Liu, Xiaohua ^{[1
]}

Wang, Wentao ^{[1
]}

Lin, Lili ^{[1
]}

Feng, Xiaoming ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 04期

基金：

中国国家自然科学基金;

关键词：

H BOND FUNCTIONALIZATION; FRIEDEL-CRAFTS ALKYLATION; DIELS-ALDER REACTION; ASYMMETRIC HYDROGENATION; EFFICIENT SYNTHESIS; MICHAEL ADDITION; REDOX PROCESS; QUINOLINES; COMPLEX; HETEROCYCLES;

D O I：

10.1021/ol1028282

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chiral catalyst prepared from N,N '-dioxide and Co(BF4)(2)center dot 6H(2)O was applied in the asymmetric hydride transfer initiated cyclization reaction, giving optically active tetrahydroquinolines in good yields with high enantioselectivities under mild reaction conditions. Meanwhile, in light of the absolute configuration of the product, a possible working model was proposed to explain the origin of the activation and asymmetric induction.

引用

页码：600 / 603

页数：4

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