The role of prenatal alcohol exposure in abruptio placentae

被引:6
作者
du Toit, M. M. [1 ]
Smith, M. [1 ]
Odendaal, H. J. [1 ]
机构
[1] Tygerberg Acad Hosp, Dept Obstet & Gynaecol, Tygerberg, W Cape, South Africa
来源
SAMJ SOUTH AFRICAN MEDICAL JOURNAL | 2010年 / 100卷 / 12期
关键词
MATERNAL RISK-FACTORS; SEVERE PREECLAMPSIA; PREGNANT-WOMEN; SOUTH-AFRICA; SMOKING; CONSUMPTION; STILLBIRTH; FOLATE;
D O I
10.7196/SAMJ.4072
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To investigate the association between preconception and prenatal alcohol use and abruptio placentae. Methods. A case-control study of women with the clinical diagnosis of abruptio placentae, 65 cases and 66 controls, at Tygerberg Academic Hospital, Western Cape, South Africa. Women in whom a retroplacental blood clot, covering at least 15% of the placental surface, was found at delivery at 24 weeks' gestation or later were asked to complete a timeline follow-back questionnaire to determine their alcohol intake 12 and 3 months before and during pregnancy. The same questionnaire was administered to a control group of high-risk women who had no antepartum haemorrhage. Outcome. Women who drank alcohol 12 months before conception were more than 4 times more likely to develop abruptio placentae than the control group (odds ratio (OR) 4.49, p=0.00009). Women who drank alcohol 3 months prior to conception were 3 times more likely to develop abruptio placentae than the control group (OR 3.06, p=0.003). Drinking alcoholic beverages during pregnancy carried a more than 3 times greater risk of developing abruptio placentae (OR 3.52, p=0.0006). In the study group, women consumed a mean of 13.6, 12.0 and 11.2 standard drinks in a typical week at 12 and 3 months before and during pregnancy, respectively. The study group demonstrated a binge-drinking pattern, with two to four sessions per month. Conclusion. An association was found between preconception and prenatal consumption of alcohol and abruptio placentae.
引用
收藏
页码:832 / 835
页数:4
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