mTOR upregulation of glycolytic enzymes promotes tumor development

被引:31
作者
Zha, Xiaojun [4 ]
Sun, Qian [1 ,2 ,3 ]
Zhang, Hongbing [1 ,2 ,3 ]
机构
[1] Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Dept Physiol & Pathophysiol, Beijing 100730, Peoples R China
[2] Chinese Acad Med Sci, Sch Basic Med, Beijing 100037, Peoples R China
[3] Peking Union Med Coll, Beijing 100021, Peoples R China
[4] Anhui Med Univ, Sch Basic Med, Dept Biochem & Mol Biol, Hefei, Peoples R China
关键词
COMPLEX; CANCER;
D O I
10.4161/cc.10.7.15063
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:1015 / 1016
页数:2
相关论文
共 11 条
[1]   Regulation of cancer cell metabolism [J].
Cairns, Rob A. ;
Harris, Isaac S. ;
Mak, Tak W. .
NATURE REVIEWS CANCER, 2011, 11 (02) :85-95
[2]   Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome [J].
Corradetti, MN ;
Inoki, K ;
Bardeesy, N ;
DePinho, RA ;
Guan, KL .
GENES & DEVELOPMENT, 2004, 18 (13) :1533-1538
[3]   Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 [J].
Duevel, Katrin ;
Yecies, Jessica L. ;
Menon, Suchithra ;
Raman, Pichai ;
Lipovsky, Alex I. ;
Souza, Amanda L. ;
Triantafellow, Ellen ;
Ma, Qicheng ;
Gorski, Regina ;
Cleaver, Stephen ;
Heiden, Matthew G. Vander ;
MacKeigan, Jeffrey P. ;
Finan, Peter M. ;
Clish, Clary B. ;
Murphy, Leon O. ;
Manning, Brendan D. .
MOLECULAR CELL, 2010, 39 (02) :171-183
[4]   Defining the role of mTOR in cancer [J].
Guertin, David A. ;
Sabatini, David M. .
CANCER CELL, 2007, 12 (01) :9-22
[5]   Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation [J].
Heiden, Matthew G. Vander ;
Cantley, Lewis C. ;
Thompson, Craig B. .
SCIENCE, 2009, 324 (5930) :1029-1033
[6]   Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression [J].
Le, Anne ;
Cooper, Charles R. ;
Gouw, Arvin M. ;
Dinavahi, Ramani ;
Maitra, Anirban ;
Deck, Lorraine M. ;
Royer, Robert E. ;
Jagt, David L. Vander ;
Semenza, Gregg L. ;
Dang, Chi V. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (05) :2037-2042
[7]   Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade [J].
Ma, Jianhui ;
Meng, Yan ;
Kwiatkowski, David J. ;
Chen, Xinxin ;
Feng, Haiyong ;
Sun, Qian ;
Zha, Xiaojun ;
Wang, Fang ;
Wang, Ying ;
Jing, Yanling ;
Zhang, Shu ;
Chen, Rongrong ;
Wang, Lianmei ;
Wu, Erxi ;
Cai, Guifang ;
Malinowska-Kolodziej, Izabela ;
Liao, Qi ;
Liu, Yuqin ;
Zhao, Yi ;
Sun, Qiang ;
Xu, Kaifeng ;
Dai, Jianwu ;
Han, Jiahuai ;
Wu, Lizi ;
Zhao, Robert Chunhua ;
Shen, Huangxuan ;
Zhang, Hongbing .
JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (01) :103-114
[8]   Akt regulates growth by directly phosphorylating Tsc2 [J].
Potter, CJ ;
Pedraza, LG ;
Xu, T .
NATURE CELL BIOLOGY, 2002, 4 (09) :658-665
[9]   Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme [J].
Wolf, Amparo ;
Agnihotri, Sameer ;
Micallef, Johann ;
Mukherjee, Joydeep ;
Sabha, Nesrin ;
Cairns, Rob ;
Hawkins, Cynthia ;
Guha, Abhijit .
JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (02) :313-326
[10]   Lactate Dehydrogenase B Is Critical for Hyperactive mTOR-Mediated Tumorigenesis [J].
Zha, Xiaojun ;
Wang, Fang ;
Wang, Ying ;
He, Shaozong ;
Jing, Yanling ;
Wu, Xueyan ;
Zhang, Hongbing .
CANCER RESEARCH, 2011, 71 (01) :13-18