ACQUIRED PERFORATING DERMATOSIS. CASE REPORT OF TWO PATIENTS WITH DIABETES MELLITUS AND CHRONIC RENAL DISEASE UNDERGOING HEMODIALYSIS

被引:0
作者
Guadalupe Espin, Mercedes [1 ]
Veronica Marin, Cintia [2 ]
del Pilar Beruchi, Maria [1 ]
Lago, Rosana [1 ]
Segovia, Fernando [2 ]
Abuchanab, Matias [2 ]
机构
[1] Hosp Gen Agudos Carlos G Durand, Unidad Dermatol, Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Hosp Clin Jose de San Martin, Div Nefrol, Buenos Aires, DF, Argentina
来源
REVISTA DE NEFROLOGIA DIALISIS Y TRASPLANTE | 2018年 / 38卷 / 03期
关键词
acquired perforating dermatosis; hemodialysis; renal dialysis; mellitus diabetes; injuries; COLLAGENOSIS;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Perforating dermatoses (PD) represent a heterogeneous group of inherited or acquired diseases characterized by transepidermal migration of dermis extracellular matrix components (collagen, elastic tissue or necrotic connective tissue) following an inflammatory and/or degenerative process. The etiopathogenesis of acquired perforating dermatosis (APD) is unknown. However, it is strongly associated with minor trauma, chronic renal failure and diabetes mellitus and, less frequently, with endocrinological diseases, infectious diseases, neoplastic growth, among others. Acquired perforating dermatoses are diagnosed in 10-12 % of patients undergoing hemodialysis. Itching constitutes the main symptom of this disorder. In some cases, it may be incapacitating and secondary excoriation due to scratching may cause extensive lesions altering the skin barrier function. We report the cases of two patients undergoing hemodialysis three times a week, both with a history of diabetes mellitus and end-stage chronic renal failure requiring renal replacement therapy (RRT). These patients presented with generalized itching dermatosis which had been going on for months. Upon physical examination, raised, hyperpigmented lesions with an umbilicated center and surrounded by an erythematous halo were observed on the face, trunk and limbs. Histopathological examination revealed APD.
引用
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页码:222 / 229
页数:8
相关论文
共 25 条
[1]  
Arias M, 2007, DERMATOL ARGENT, V13, P184
[2]  
Arredondo MI, 2008, REV ASOC COL DERMATO, V16, P185
[3]  
Bolognia J, 2008, DERMATOLOGY, P1461
[4]  
Calb IL, 2005, DERMATOLOGIA PRACTIC, P1096
[5]  
Castellanos Possee ML, 2012, MED CUTAN IBERO LAT, V40, P147
[6]   Xanthine oxidase is involved in free radical production in type 1 diabetes -: Protection by allopurinol [J].
Desco, MC ;
Asensi, A ;
Márquez, R ;
Martínez-Valls, J ;
Vento, M ;
Pallardó, FV ;
Sastre, J ;
Viña, J .
DIABETES, 2002, 51 (04) :1118-1124
[7]   ACQUIRED REACTIVE PERFORATING COLLAGENOSIS - REPORT OF 6 CASES AND REVIEW OF THE LITERATURE [J].
FAVER, IR ;
DAOUD, MS ;
SU, WPD .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1994, 30 (04) :575-580
[8]   AGE-Modified Collagens I and III Induce Keratinocyte Terminal Differentiation through AGE Receptor CD36: Epidermal-Dermal Interaction in Acquired Perforating Dermatosis [J].
Fujimoto, Eita ;
Kobayashi, Takashi ;
Fujimoto, Norihiro ;
Akiyama, Minoru ;
Tajima, Shingo ;
Nagai, Ryoji .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (02) :405-414
[9]   Up-regulation of transforming growth factor-β3 and extracellular matrix proteins in acquired reactive perforating collagenosis [J].
Gambichler, Thilo ;
Birkner, Lukas ;
Stuecker, Markus ;
Othlinghaus, Nick ;
Altmeyer, Peter ;
Kreuter, Alexander .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 60 (03) :463-469
[10]  
Garcia-Salcesa I, 2008, PIEL, V23, P341