Granada Virus: a Natural Phlebovirus Reassortant of the Sandfly Fever Naples Serocomplex with Low Seroprevalence in Humans

被引：64
作者：
Collao, Ximena [1 ]
Palacios, Gustavo [2 ]
de Ory, Fernando [3 ]
Sanbonmatsu, Sara [4 ]
Perez-Ruiz, Mercedes [4 ]
Maria Navarro, Jose [4 ]
Molina, Ricardo [5 ]
Hutchison, Stephen K.
Lipkin, W. Ian [2 ]
Tenorio, Antonio [1 ]
Paz Sanchez-Seco, Maria [1 ]
机构：
[1] Inst Hlth Carlos III, Natl Ctr Microbiol, Lab Arbovirus & Imported Viral Dis, Ctra Pozuelo Majadahonda Km 2, Madrid 28220, Spain
[2] Columbia Univ, Mailman Sch Publ Hlth, Ctr Infect & Immun, New York, NY USA
[3] Inst Hlth Carlos III, Natl Ctr Microbiol, Serol Sect, Madrid 28220, Spain
[4] Univ Hosp Virgen Nieve, Microbiol Serv, Granada, Spain
[5] Inst Hlth Carlos III, Natl Ctr Microbiol, Serv Parasitol, Madrid 28220, Spain
来源：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2010年 / 83卷 / 04期
基金：
美国国家卫生研究院;
关键词：
CENTRAL-NERVOUS-SYSTEM; M-SEGMENT REASSORTMENT; TOSCANA VIRUS; MOLECULAR-IDENTIFICATION; CLINICAL-SAMPLES; INFECTIONS; SUBSTITUTIONS; DETERMINANTS;
D O I：
10.4269/ajtmh.2010.09-0697
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
A new member of the phlebovirus genus, tentatively named Granada virus, was detected in sandflies collected in Spain. By showing the presence of specific neutralizing antibodies in human serum collected in Granada, we show that Granada virus infects humans. The analysis of the complete genome of Granada virus revealed that this agent is likely to be a natural reassortant of the recently described Massilia virus (donor of the long and short segments) with a yet unidentified phlebovirus (donor of the medium segment).
引用
收藏
页码：760 / 765
页数：6
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