Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor

被引：6

作者：

Jones, Lyn H.

Randall, Amy

Barba, Oscar

Selby, Matthew D.

机构：

[1] OSI Pharmaceut, Oxford OX4 6LT, England

[2] Pfizer Global Res & Dev, Sandwich Labs, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 21期

关键词：

D O I：

10.1039/b714091f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the process of developing a series of novel, fluorinated biaryl ether NNRTIs, we fortuitously discovered derivative 20, which possesses excellent potency against both wild-type and clinically relevant mutations of the reverse transcriptase enzyme.

引用

收藏

页码：3431 / 3433

页数：3

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