Growth hormone replacement therapy (GHRT) in children and adolescents: Skeletal impact

被引：6

作者：

Mukherjee, A ^{[1
]}

Shalet, SM ^{[1
]}

机构：

[1] Christie Hosp, Dept Endocrinol, Manchester M20 4BX, Lancs, England

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 2003年 / 41卷 / 03期

关键词：

childhood-onset GHD; GH replacement; BMD; final height; peak bone mass;

D O I：

10.1002/mpo.10343

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In addition to its well-established effects on linear growth in childhood and adolescence, growth hormone has both direct and indirect actions on bone remodelling and homeostasis. In this review the limitations of methods of assessment of bone mineral density are highlighted. The influence of growth hormone deficiency of childhood-onset, on bone mineral accretion and, the specific skeletal implications of GHD in long-term survivors of childhood cancers, are discussed. Specific influential factors, which affect peak bone mass achievement and therefore skeletal health in later life, are evaluated. (C) 2003 Wiley-Liss, Inc.

引用

页码：235 / 242

页数：8

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