Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides

被引：8

作者：

Amorim, Gustavo Moreira ^{[1
,2
,3
,4
]}

Niemeyer Corbellini, Joao Paulo ^{[1
,2
]}

Quintella, Danielle Carvalho ^{[1
]}

Cuzzi, Tullia ^{[1
,2
,5
,6
]}

Ramos-e-Silva, Marcia ^{[1
,2
,7
]}

机构：

[1] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Dermatol Div, Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Anat Pathol Div, Rio De Janeiro, RJ, Brazil

[3] Univ Fed Rio de Janeiro, Fac Med, Hosp Univ Clementino Fraga Filho, Program Postgrad Anat Pathol, Rio De Janeiro, RJ, Brazil

[4] Univ Sul de Santa Catarina, Fac Med, Outpatient Clin Dermatol, Palhoca, SC, Brazil

[5] Univ Fed Rio de Janeiro, Dept Pathol, Rio De Janeiro, RJ, Brazil

[6] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, RJ, Brazil

[7] Univ Fed Rio de Janeiro, Fac Med, Discipline Dermatol, Rio De Janeiro, RJ, Brazil

来源：

ANAIS BRASILEIROS DE DERMATOLOGIA | 2018年 / 93卷 / 05期

关键词：

Lymphoma; T-cell; cutaneous; Mycosis fungoides; SEZARY-SYNDROME; DISEASE PROGRESSION; CLASSIFICATION; ORGANIZATION; SURVIVAL; PROPOSAL; OUTCOMES; SOCIETY; COHORT; CLIPI;

D O I：

10.1590/abd1806-4841.20187134

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BACKGROUND: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. OBJECTIVE: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. METHODS: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. RESULTS: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 -1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. STUDY LIMITATIONS: Small sample and its retrospective analysis. CONCLUSIONS: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.

引用

页码：680 / 685

页数：6

共 17 条

[1] Survival Outcomes and Prognostic Factors in Mycosis Fungoides/Sezary Syndrome: Validation of the Revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer Staging Proposal [J].