Progress report on new antiepileptic drugs: a summary of the Fifth Eilat Conference (EILAT V)

被引：140

作者：

Bialer, M ^{[1
]}

Johannessen, SI

Kupferberg, HJ

Levy, RH

Loiseau, P

Perucca, E

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, David R Bloom Ctr Pharm, IL-91120 Jerusalem, Israel

[3] Natl Ctr Epilepsy, Sandvika, Norway

[4] NINDS, Epilepsy Branch, Bethesda, MD USA

[5] Univ Washington, Dept Pharmaceut & Neurol Surg, Seattle, WA USA

[6] Bordeaux Univ, Hosp Pellegrin, Dept Neurol, Bordeaux, France

[7] Univ Pavia, Dept Internal Med & Therapeut, Clin Pharmacol Unit, Pavia, Italy

来源：

EPILEPSY RESEARCH | 2001年 / 43卷 / 01期

关键词：

antiepileptic drugs; drug development; epilepsy; pharmacology; clinical trials; conference;

D O I：

10.1016/S0920-1211(00)00171-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Fifth Eilat Conference on New Antiepileptic Drugs (AEDs) took place at the Dan Hotel, Eilat, Israel, 25-29 June 2000. Basic scientists, clinical pharmacologists and neurologists from 20 countries attended the conference, whose main themes included recognition of unexpected adverse effects, new indications of AEDs, and patient-tailored AED therapy. According to tradition, the central part of the conference was devoted to a review of AEDs in development, as well to updates on AEDs that have been marketed in recent years. This article summarizes the information presented on drugs in preclinical and clinical development, including AWD 131-138, DP-valproate, harkoseride, LY300164, NPS 1776, NW 1015. pregabalin, remacemide, retigabine, rufinamide and valrocemide. The potential value of an innovative strategy, porcine embryonic GABAergic cell transplants, is also discussed. Finally, updates on felbamate, fosphenytoin, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, tiagabine, topiramate, vigabatrin, zonisamide, and the antiepileptic vagal stimulator device are presented. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：11 / 58

页数：48

共 198 条

[1] Tiagabine - A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of epilepsy [J].

Adkins, JC ;

Noble, S .

DRUGS, 1998, 55 (03) :437-460

[2]

ALHAGEN S, 1997, EPILIPSIA, V38, P207

[3] Epilepsy, vagal nerve stimulation by the NCP system mortality, and sudden, unexpected, unexplained death [J].

Annegers, JF ;

Coan, SP ;

Hauser, WA ;

Leestma, J ;

Duffell, W ;

Tarver, B .

EPILEPSIA, 1998, 39 (02) :206-212

[4]

Appleton R, 2000, BRIT MED J, V320, P1404

[5] Gabapentin as add-on therapy in children with refractory partial seizures: A 12-week, multicentre, double-blind, placebo-controlled study [J].

Appleton, R ;

Fichtner, K ;

Lamoreaux, L ;

Alexander, J ;

Halsall, G ;

Murray, G ;

Garofalo, E .

EPILEPSIA, 1999, 40 (08) :1147-1154

[6] Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms [J].

Appleton, RE ;

Peters, ACB ;

Mumford, JP ;

Shaw, DE .

EPILEPSIA, 1999, 40 (11) :1627-1633

[7] Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex hippocampal slices [J].

Armand, V ;

Rundfeldt, C ;

Heinemann, U .

EPILEPSIA, 2000, 41 (01) :28-33

[8] Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices [J].

Armand, V ;

Rundfeldt, C ;

Heinemann, U .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1999, 359 (01) :33-39

[9] Bradycardia and asystole with the use of vagus nerve stimulation for the treatment of epilepsy:: A rare complication of intraoperative device testing [J].

Asconapé, JJ ;

Moore, DD ;

Zipes, DP ;

Hartman, LM ;

Duffell, WH .

EPILEPSIA, 1999, 40 (10) :1452-1454

[10]

Ayala R, 1998, NEUROLOGY, V50, pA313

← 1 2 3 4 5 6 7 8 9 10 →