Regulation of lipid droplet turnover by ubiquitin ligases

被引：10

作者：

Alberts, Philipp ^{[1
]}

Rotin, Daniela

机构：

[1] Univ Toronto, Cell Biol Program, Hosp Sick Children, Toronto, ON M5G 1L7, Canada

来源：

BMC BIOLOGY | 2010年 / 8卷

关键词：

TROYER-SYNDROME; PROMOTES; SPARTIN; DOMAIN; ITCH;

D O I：

10.1186/1741-7007-8-94

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ubiquitination and degradation of droplet-associated proteins. A deficiency of spartin apparently causes lipid droplets to accumulate.

引用

页数：3

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