Molecular mechanisms of glioma invasiveness: The role of proteases

被引：694

作者：

Rao, JS ^{[1
]}

机构：

[1] Univ Illinois, Coll Med, Dept Neurosurg, Program Canc Biol, Peoria, IL 61656 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1121

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The invasive nature of brain-tumour cells makes an important contribution to the ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably infiltrate the surrounding normal brain tissue, which leads to tumour recurrence. Such local invasion remains an important cause of mortality and underscores the need to understand in more detail the mechanisms of tumour invasiveness. Several proteases influence the malignant characteristics of gliomas could their inhibition prove to be a useful therapeutic strategy?

引用

页码：489 / 501

页数：13

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