Two novel furostanol saponins from the rhizomes of Dioscorea panthaica Prain et Burkill and their cytotoxic activity

被引：100

作者：

Dong, M

Feng, XZ

Wang, BX ^{[1
]}

Wu, LJ

Ikejima, T

机构：

[1] Chanchun Coll Tradit Chinese Med, Res Ctr New Drugs, Changchun 130021, Peoples R China

[2] Shenyang Pharmaceut Univ, Dept Nat Med Chem, Shenyang 110015, Peoples R China

来源：

TETRAHEDRON | 2001年 / 57卷 / 03期

关键词：

Dioscorea panthaica; furostanol saponins; cytotoxic activity;

D O I：

10.1016/S0040-4020(00)01024-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dioscoresides A and B were isolated from the rhizomes of Dioscorea panyhaica and shown to possess a novel furostanol skeleton. Their structures were fully elucidated as 3-O-[beta -D-glucopyranosyl-(1-->3)-O-alpha -L-rhamnopyranosyl-(1-->2)-beta -D-glucopyranosyl]-26-O-P-20, 22-seco-D-glucopyranosyl-25 (R)-furosta-5-en-20, 22-dione-3 beta, 26-diol and 3-O-[bis-alpha -L-rhamnopyranosyl-(1-->4 and 1-->2)-beta -D-glucopyranosyl]-26-O-beta -D-glucopyranosyl-20, 22-seco-25 (R)-furosta-5-en-20, 22-dione-3 beta, 23(S), 26-triol by spectroscopic techniques and chemical means. These compounds exhibited cytotoxic activity tested in vitro on A375-S2, L929 and Hela cell lines. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：501 / 506

页数：6

共 14 条

[1] New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi [J].