Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus

被引：63
|
作者：
Chambers, HF
机构：
[1] San Francisco Gen Hosp, Div Infect Dis, San Francisco, CA 94110 USA
[2] Univ Calif San Francisco, San Francisco, CA 94110 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 03期
关键词：
D O I：
10.1128/AAC.49.3.884-888.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ceftobiprole is a novel broad-spectrum cephalosporin that binds with high affinity to PBP 2a, the methicillin-resi stance determinant of staphylococci, and is active against methicillin- and vancomycin-resistant Staphylococcus aureus. Ceftobiprole was compared to vancomycin in a rabbit model of methicillin-resistant S. aureus aortic valve endocarditis. Ceftobiprole and vancomycin were equally effective against endocarditis caused by methicillin-resistant S. aureus strain 76, whereas ceftobiprole was more effective than vancomycin against the vancomycin-intermediate S. aureus strain HIP5836. The activity of ceftobiprole against drug-resistant strains of S. aureus warrants its further clinical development.
引用
收藏
页码：884 / 888
页数：5
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