Tackling mastitis in dairy cows

被引:24
作者
Rainard, P [1 ]
机构
[1] INRA, Pathol Infect & Immunol Lab, Natl Inst Agron Res, F-37380 Nouzilly, France
关键词
D O I
10.1038/nbt0405-430
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Transgenic cows expressing an antibacterial endopeptidase in their mammary glands show enhanced resistance to mastitis.
引用
收藏
页码:430 / 432
页数:4
相关论文
共 8 条
[1]   Mechanism and suppression of lysostaphin resistance in oxacillin-resistant Staphylococcus aureus [J].
Climo, MW ;
Ehlert, K ;
Archer, GL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (05) :1431-1437
[2]  
Kerr DE, 2003, J ANIM SCI, V81, P38
[3]   Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice [J].
Kerr, DE ;
Plaut, K ;
Bramley, AJ ;
Williamson, CM ;
Lax, AJ ;
Moore, K ;
Wells, KD ;
Wall, RJ .
NATURE BIOTECHNOLOGY, 2001, 19 (01) :66-70
[4]   Engineering immunity in the mammary gland [J].
Kolb, AF .
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2002, 7 (02) :123-134
[5]   LYSOSTAPHIN - USE OF A RECOMBINANT BACTERICIDAL ENZYME AS A MASTITIS THERAPEUTIC [J].
OLDHAM, ER ;
DALEY, MJ .
JOURNAL OF DAIRY SCIENCE, 1991, 74 (12) :4175-4182
[6]   Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria [J].
Smith, DL ;
Harris, AD ;
Johnson, JA ;
Silbergeld, EK ;
Morris, JG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (09) :6434-6439
[7]   Large scale production of recombinant human lactoferrin in the milk of transgenic cows [J].
van Berkel, PHC ;
Welling, MM ;
Geerts, M ;
van Veen, HA ;
Ravensbergen, B ;
Salaheddine, M ;
Pauwels, EKJ ;
Pieper, F ;
Nuijens, JH ;
Nibbering, PH .
NATURE BIOTECHNOLOGY, 2002, 20 (05) :484-487
[8]   Genetically enhanced cows resist intramammary Staphylococcus aureus infection [J].
Wall, RJ ;
Powell, AM ;
Paape, MJ ;
Kerr, DE ;
Bannerman, DD ;
Pursel, VG ;
Wells, KD ;
Talbot, N ;
Hawk, HW .
NATURE BIOTECHNOLOGY, 2005, 23 (04) :445-451