Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice

被引：126

作者：

Poncelet, M ^{[1
]}

Maruani, J ^{[1
]}

Calassi, R ^{[1
]}

Soubrié, P ^{[1
]}

机构：

[1] Sanofi Synthelabo Rech, Cent Nervous Syst Dept, F-34184 Montpellier 04, France

来源：

NEUROSCIENCE LETTERS | 2003年 / 343卷 / 03期

关键词：

CB1 knockout mice; SR141716; neuropeptide Y; ethanol drinking; sucrose intake;

D O I：

10.1016/S0304-3940(03)00397-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Administration of the cannabinoid CBI receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CBI vs. CB1 +/+ mice. In CB1 deficient mice, SR141716 had no effect in these models. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：216 / 218

页数：3

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